Pineal photoreceptors rhythmically secrete melatonin.
Pineal photoreceptors rhythmically secrete melatonin.
复制标题
松果体感光器有节奏地分泌褪黑激素。
DOI：
10.1016/0304-3940(94)90617-3
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发表时间：
1994
影响因子：
2.5
通讯作者：
Tang,WX
中科院分区：
文献类型：
--
作者：
Pickard,GE;Tang,WX
单个松果体细胞以昼夜节律周期分泌褪黑激素，将脊椎动物昼夜节律系统降低到单个细胞的水平[Brain Res.，627（1993）141-146]。在本研究中，分离的松果体细胞被确定为褪黑激素分泌的反向溶血空斑试验（RHPA）和所有褪黑激素分泌细胞的感光蛋白S-抗原分析时，免疫阳性。这些结果是第一个直接的证据表明，孤立的感光细胞分泌褪黑激素，并采取与我们以前的研究结果表明，单个松果体细胞包含：（1）昼夜节律振荡器;（2）光感受能力;（3）有节奏地分泌褪黑激素的能力。
Individual pineal cells secrete melatonin with a circadian period, reducing a vertebrate circadian system to the level of a single cell [Brain Res., 627 (1993) 141–146]. In the present study, dissociated pineal cells were identified as melatonin-secreting by a reverse hemolytic plaque assay (RHPA) and all melatonin-secreting cells were immuno-positive when analyzed for the photoreceptor protein S-antigen. The results are the first direct evidence that isolated photoreceptor cells secrete melatonin and taken together with our previous findings indicate that single pineal cells contain: (1) a circadian oscillator; (2) a photoreceptive capacity; and (3) the ability to secrete melatonin rhythmically.