PHENOTYPIC MODULATION OF THE CANINE PROSTATE AFTER LONG-TERM TREATMENT WITH ANDROGENS AND ESTROGENS
PHENOTYPIC MODULATION OF THE CANINE PROSTATE AFTER LONG-TERM TREATMENT WITH ANDROGENS AND ESTROGENS
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DOI：
10.1002/pros.2990030406
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发表时间：
1982-01-01
期刊：
影响因子：
2.8
通讯作者：
NEUMANN, F
中科院分区：
文献类型：
--
作者：
AUMULLER, G;FUNKE, PJ;NEUMANN, F
通过长期使用雌激素和/或雄激素以及联合使用抗雄激素和/或抗雌激素治疗6个月，研究了被阉割的成年动物犬前列腺的细微结构变化，特别是它们在腺体内的地形位置。上皮结构反应主要表现为鳞状化生、萎缩和肥大，间质反应主要表现为退变、肥大或硬化。除了间质纤维细胞和平滑肌细胞的细胞改变外，不同间质成分的排列、分布和模式也发生了特征性的变化。在雌二醇和雄烯二醇联合治疗的动物中，上皮的一般鳞状化生和间质细胞的退行性改变最为明显。抗雄激素阉割动物的显著特征是上皮萎缩和基质硬化，而雄甾二醇替代的阉割动物的主要发现是上皮和基质肥大或增生。联合治疗引起相当异质的结构模式，似乎依赖于腺体内的位置。显然，前列腺上皮细胞处理各种各样的结构反应模式，在联合激素治疗的情况下，以一种典型的方式表达它们在腺体导管系统中的位置。除了对去势犬进行雌二醇、他莫昔芬和雄甾二醇联合治疗外，所采用的实验方案均未引起可与人类良性前列腺增生（BPH）相媲美的腺体形态反应。因此，犬前列腺作为人类前列腺增生模型的价值相当有限。
Fine structural alterations of the canine prostate induced by long-term treatment of castrated adult animals with estrogens and/or androgens and also in combination with antiandrogens and/or antiestrogens for 6 mo. were studied with particular respect to their topographic location within the gland. Three major patterns of structural responses of the epithelium were distinguished: squamous metaplasia, atrophy and hypertrophy, while in stroma, regression, hypertrophy or sclerosis were observed. In addition to cellular alterations of stromal fibrocytes and smooth muscle cells, characteristic changes in the arrangement, distribution and pattern of the different stromal elements occurred. General squamous metaplasia of the epithelium and regressive alterations of stromal cells were most obvious in animals treated with estradiol plus androstanediol. Atrophy of the epithelium and stromal sclerosis were the salient features of antiandrogen-treated castrated animals, while hypertrophy or hyperplasia of both the epithelium and stroma was a major finding in androstanediol-substituted castrated animals. Combined treatment caused rather heterogeneous structural patterns seemingly dependent on the location within the gland. Apparently, the prostatic epithelial cells dispose of a broad variety of structural reaction patterns that, in case of combined hormonal treatment, are expressed in a manner typical for their locations within the ductal system of the gland. With the exception of combined treatment with estradiol, tamoxifen and androstanediol of castrated dogs, none of the experimental protocols used induced a morphologic response of the gland comparable to that seen in human benign prostatic hyperplasia [BPH]. The canine prostate therefore is of rather limited value as a model for human BPH.