Cytogenetic effects of the herbicide chloridazon in cultured sheep lymphocytes.
Cytogenetic effects of the herbicide chloridazon in cultured sheep lymphocytes.
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除草剂氯草酮对培养的绵羊淋巴细胞的细胞遗传学影响。
DOI：
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发表时间：
1997
影响因子：
0.9
通讯作者：
J. Dianovskỳ
中科院分区：
文献类型：
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作者：
K. Šiviková;J. Dianovskỳ
本文研究了除草剂杀螟松对体外培养的绵羊外周血淋巴细胞染色体畸变（CA）和姐妹染色单体交换（SCE）的影响。在存在和不存在S9组分的情况下，在剂量为7 x 10（-4）M的氯达松处理培养物中均观察到阳性致染色体断裂效应，但在较低剂量（分别为7 x 10（-6）M和7 x 10（-5）M）下未观察到染色体断裂显著增加。氯达松诱导SCE的效力存在明显的剂量依赖性和显著差异。与对照组相比，未观察到细胞周期延迟的诱导。
The effect of in vitro exposure to the herbicide chloridazon on the induction of chromosome aberrations (CA) and sister chromatid exchanges (SCE) was studied in cultured sheep peripheral lymphocytes. A positive clastogenic effect was observed in chloridazon-treated cultures at a dose of 7 x 10(-4) M both in the presence and absence of the S9 fraction, but no significant increase of chromosome breaks was seen at lower doses (7 x 10(-6) M and 7 x 10(-5) M, respectively). A clear dose-dependence and significant differences were found in chloridazon potency to induce SCEs. Induction of cell cycle delays as compared to the controls was not observed.