Determination of major radionuclidic impurities in K99TcO4 pharmaceutical raw material
Determination of major radionuclidic impurities in K99TcO4 pharmaceutical raw material
复制标题
DOI：
10.1007/s10967-021-07902-w
复制
发表时间：
2021-09
影响因子：
1.6
通讯作者：
Maoyi Luo;Ji Hu;S. Xing;Yang Wu;Daqian Liu;X. Dai
中科院分区：
文献类型：
--
作者：
Maoyi Luo;Ji Hu;S. Xing;Yang Wu;Daqian Liu;X. Dai
本文介绍了一种连续分离和测定99Tc放射性药物原料中最重要的α和β放射性核素杂质的快速分析方法。为了避免99Tc对液闪法测定β放射性核素的光谱干扰，采用了连续HTO共沉淀法去除99Tc。采用连续色谱法同时分离纯化锕系元素和镧系元素同位素。对一系列已知量的238 Pu、239 Pu、241 Pu、237 Np、241 Am、244 Cm和147 Pm的K99 TcO4溶液进行了分析评价，结果表明，该方法能够满足K99 TcO4原料放射性核素杂质评价的分析要求。
A rapid analytical method for sequential separation and determination of the most significant α- and β-emitting radionuclidic impurities in99Tc radiopharmaceutical raw material is presented. Successive HTiO co-precipitation steps were first conducted for effective removal of99Tc to avoid its spectral interference on the determination of β-emitting nuclides by liquid scintillation counting. A sequential chromatographic method was applied for simultaneous separation and purification of actinide and lanthanide isotopes. A series of K99TcO4solution spiked with known quantities of238Pu,239Pu,241Pu,237Np,241Am,244Cm and147Pm were analyzed for method evaluation, demonstrating that the method would meet the analytical requirements for radionuclidic impurity evaluation of K99TcO4raw material.