Host Response Cytokine Signatures in Viral and Nonviral Acute Exacerbations of Chronic Obstructive Pulmonary Disease
Host Response Cytokine Signatures in Viral and Nonviral Acute Exacerbations of Chronic Obstructive Pulmonary Disease
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DOI：
10.1089/jir.2010.0131
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发表时间：
2011-05-01
影响因子：
2.3
通讯作者：
Bermejo-Martin, Jesus F.
中科院分区：
文献类型：
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作者：
Almansa, Raquel;Sanchez-Garcia, Monica;Bermejo-Martin, Jesus F.
病毒与慢性阻塞性肺疾病急性加重（AECOPD）密切相关。干扰素诱导蛋白-10最近被描述为人类鼻病毒感染的生物标志物，但还没有关于其他免疫介质在病毒源性AECOPD中的作用的报道。为了评估存在/不存在病毒感染的AECOPD患者之间全身免疫介质谱的差异，我们使用基于Luminex的测定法测量了40例需要住院治疗的AECOPD患者血浆中的27种细胞因子、趋化因子和细胞生长因子。对这些患者的咽拭子进行了16种不同呼吸道病毒的筛查。为了比较的目的，招募了10名健康对照。有相关病毒感染的患者组（n = 11）和无病毒感染的患者组（n = 29）均显示出高水平的血管内皮生长因子、白细胞介素-13（IL-13）和IL-2。另一方面，AECOPD中的病毒感染诱导了先天免疫趋化因子（嗜酸性粒细胞趋化因子、干扰素诱导蛋白-10、IL-8）、Th 1细胞因子（IL-12 p70、IL-15）和免疫调节性IL-10的协调应答。该特征对应于先前记录的其他病毒感染的典型抗病毒应答特征。在AECOPD中识别与病毒感染相关的早期细胞因子特征可能有助于设计更好的治疗策略。
Viruses are strongly associated with acute exacerbations of chronic obstructive pulmonary disease (AECOPD). Interferon-inducible protein-10 has been recently described as a biomarker of human rhinovirus infection, but there are no reports on the role of other immune mediators in AECOPD of viral origin. As an attempt to evaluate the differences in the systemic immune mediators profiles between AECOPD patients with presence/absence of viral infection, we measured 27 cytokines, chemokines, and cellular growth factors in the plasma of 40 patients with AECOPD needing of hospitalization by using a Luminex-based assay. These patients were screened for the presence of 16 different respiratory viruses in pharyngeal swabs. Ten healthy controls were recruited for comparison purposes. Both the group of patients with an associated viral infection (n = 11) and those with no viral infection (n 29) showed high levels of vascular endothelial growth factor, interleukin-13 (IL-13), and IL-2. On the other hand, viral infection in AECOPD induced a coordinated response of innate immunity chemokines (eotaxin, interferon-inducible protein-10, IL-8), Th1 cytokines (IL-12p70, IL-15), and the immunomodulatory IL-10. This profile corresponds to a typical antiviral response signature previously documented for other viral infections. The identification of early cytokine signatures associated with viral infection in AECOPD could contribute to design better treatment strategies for this disease.