Treatment outcome in children with malignancies associated with human immunodeficiency virus infection.
Treatment outcome in children with malignancies associated with human immunodeficiency virus infection.
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人类免疫缺陷病毒感染相关恶性肿瘤儿童的治疗结果。
DOI：
10.1016/s0022-3476(05)82660-5
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Clavell,LA
中科院分区：
文献类型：
--
作者：
Montalvo,FW;Casanova,R;Clavell,LA
与人类免疫缺陷病毒1型感染相关的疾病谱包括继发性恶性肿瘤。1在成人中，最常见的继发性恶性肿瘤是卡波西肉瘤和淋巴瘤，2它们可能在同一患者中共存。淋巴瘤最常见的是B细胞高级别淋巴瘤。14中枢神经系统原发性淋巴瘤常见于成人获得性免疫缺陷综合征患者，占所有艾滋病相关淋巴瘤的10%。[2]最近，Epstein等人5报告了三例儿童病例。成人艾滋病相关恶性肿瘤治疗的总体结果不佳6;许多患者在感染后早期死亡、早期复发或尽管进行了化疗但仍进行性疾病。在这份报告中，我们描述了三名儿童艾滋病谁是以前很好，但有艾滋病相关的恶性肿瘤在介绍时]病例报告患者1。一名静脉注射药物滥用者的两岁女童在大学儿科医院首次检查左下颌下区域肿块前两周被另一家医院收治。尽管进行了肠外抗生素治疗，肿块仍继续增大，14天内，她出现双侧颧弓肿胀和进行性肥大。
The spectrum of disease related to infection with human immunodeficiency virus type 1 includes secondary malignancies. 1 In adults, the most frequent secondary malignancies are Kaposi sarcoma and lymphomas, 2 which may coexist in the same patient. The lymphomas are most often B cell high-grade lymphomas. l4 Primary lymphomas of the central nervous system are common in adults with acquired immunodeficiency syndrome, representing 10% of all AIDS-related lymphomas. 2 Recently, Epstein et al. 5 reported three such cases in children. The overall result of therapy for AIDS-related malignancies in adults has been poor6; many patients have an early death after infections, early relapse, or progressive disease in spite of chemotherapy. In this report we describe three children with AIDS who were previously well but had AIDS-related malignancies at the time of presentation]CASE REPORTS Patient 1. A 2-year-old female child of abusers of intravenous drugs had been admitted to another hospital 2 weeks before her first examination at the University Pediatric Hospital for a mass in the left submandibular region. In spite of parenteral antibiotic therapy, the mass continued to grow, and within 14 days she had bilateral swelling over the zygomatic arches and progressive hypertrophy of