Alteration of GyrA amino acid required for ciprofloxacin resistance in Klebsiella pneumoniae isolates in China
Alteration of GyrA amino acid required for ciprofloxacin resistance in Klebsiella pneumoniae isolates in China
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DOI：
10.1128/aac.00151-08
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发表时间：
2008-08-01
影响因子：
4.9
通讯作者：
Zhang, Fengmin
中科院分区：
文献类型：
--
作者：
Fu, Yingmei;Guo, Lishuang;Zhang, Fengmin
中国产肺炎克雷伯菌111株（48.1%）对环丙沙星耐药。在环丙沙星耐药和环丙沙星敏感的分离株中发现了GyrA的改变。结果，包括先前发表的数据，表明单替换Ser83 -> Ile和Ser83和Asp87的三种双突变是环丙沙星耐药所必需的（P < 0.05）。
Resistance to ciprofloxacin was detected in 111 (48.1%) isolates of Klebsiella pneumoniae from China. GyrA alterations were identified in the ciprofloxacin-resistant and ciprofloxacin-susceptible isolates. The results, including previously published data, indicate that the single substitution Ser83 -> Ile and three types of double mutations at Ser83 and Asp87 were required for ciprofloxacin resistance (P < 0.05).