Lipid-based nutrient supplementation in the first 1000 d improves child growth in Bangladesh: a cluster- randomized effectiveness trial
Lipid-based nutrient supplementation in the first 1000 d improves child growth in Bangladesh: a cluster- randomized effectiveness trial
复制标题
DOI：
10.3945/ajcn.116.147942
复制
发表时间：
2017-04-01
影响因子：
7.1
通讯作者：
Vosti, Stephen A.
中科院分区：
文献类型：
--
作者：
Dewey, Kathryn G.;Mridha, Malay K.;Vosti, Stephen A.
背景：线性生长发育迟缓主要发生在从受孕到24月龄的前1000天。尽管认识到这一关键时期，但对覆盖这一窗口期大部分时间的干预措施的增长影响的评估很少。目的：我们评估家庭强化方法在社区卫生计划中预防孕产妇和儿童营养不良。我们假设，在怀孕期间和产后前6个月向妇女提供少量基于脂质的营养补充剂（LNSs），在6至24个月向其后代提供LNSs，或两者同时提供LNSs，会导致24个月时的儿童年龄长度z评分（LAZ）高于在怀孕期间和产后向妇女提供铁和叶酸（IFA）加微量营养素粉（MNP）或在6至24个月时不补充。我们进行了一项四组的集群随机有效性试验：1)妇女和儿童均接受lns （LNS-LNS组），2)妇女接受IFA和儿童接受lns （IFA- lns组），3)妇女接受IFA和儿童接受MNP （IFA-MNP组），4)妇女接受IFA和儿童不接受补充剂（IFA-对照组）。我们招募了4011名女性
Background: Stunting in linear growth occurs mainly during the first 1000 d, from conception through 24 mo of age. Despite the recognition of this critical period, there have been few evaluations of the growth impact of interventions that cover most of this window.Objective: We evaluated home fortification approaches for preventing maternal and child undernutrition within a community-based health program. We hypothesized that small-quantity lipid-based nutrient supplements (LNSs) provided to women during pregnancy and the first 6 mo postpartum, LNSs provided to their offspring from 6 to 24 mo of age, or both would result in greater child length-for-age z score (LAZ) at 24 mo than iron and folic acid (IFA) provided to women during pregnancy and postpartum plus micronutrient powder (MNP) or no supplementation for their offspring from 6 to 24 mo.Design: We conducted a cluster-randomized effectiveness trial with 4 arms: 1) women and children both received LNSs (LNS-LNS group), 2) women received IFA and children received LNSs (IFA-LNS group), 3) women received IFA and children received MNP (IFA-MNP group), and 4) women received IFA and children received no supplements (IFA-Control group). We enrolled 4011 women at