Transdermal nicotine administration and the electroencephalographic activity of substance abusers in treatment.
Transdermal nicotine administration and the electroencephalographic activity of substance abusers in treatment.
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经皮尼古丁给药和治疗中药物滥用者的脑电图活动。
DOI：
10.1097/adm.0b013e31818b4e27
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发表时间：
2008
影响因子：
5.5
通讯作者：
Nixon,SaraJo
中科院分区：
文献类型：
--
作者：
Ceballos,NatalieA;Tivis,Rick;Prather,Robert;Nixon,SaraJo
目的：人们普遍认为，酒精或非法药物滥用障碍的个人经常吸烟。然而，很少有研究检查尼古丁对药物滥用亚组的直接影响。目前的研究检查了酒精依赖，兴奋剂依赖，酒精和兴奋剂依赖的参与者和社区控制的脑电图（EEG）活动模式。所有参与者都是经常smoker.Methods：尼古丁戒断过夜后，受试者被给予高（14或21毫克）或低（7毫克）剂量的尼古丁透皮贴剂。EEG数据收集在2分钟的眼睛打开和5分钟的眼睛关闭的基线记录会话，这是发生在一个更大的研究的一部分，大脑electrophysiology.Results：最有趣的发现是一个差异模式的尼古丁剂量效应组。脑电图的控制和酒精和兴奋剂依赖的参与者没有区分高和低尼古丁剂量，而尼古丁管理的酒精依赖和兴奋剂依赖组导致相反的结果在一系列的光谱bands.Conclusions：虽然进一步的研究是必要的，这些结果可能有影响的戒烟和药物滥用者在治疗中的注意力功能的研究。这些数据表明，尼古丁相关的神经生理学变化可能与特定的大脑区域和/或特定的药物史有关，并加强了在这些群体中推广的谨慎性。
Objectives:It is widely recognized that individuals with alcohol or illicit substance abuse disorders often smoke cigarettes. However, few studies have examined the direct effects of nicotine among substance abuse subgroups. The current study examined patterns of electroencephalographic (EEG) activity in alcohol-dependent, stimulant-dependent, alcohol-and stimulant-dependent participants, and community controls. All participants were regular smokers.Methods:After overnight nicotine abstinence, subjects were administered either a high (14 or 21 mg) or low (7 mg) dose transdermal nicotine patch. EEG data were collected during a 2-minute eyes open and 5-minute eyes closed baseline recording session, which occurred as part of a larger study of brain electrophysiology.Results:The most interesting finding was a differential pattern of nicotine dose effects by group. EEGs of controls and alcohol-and stimulant-dependent participants did not distinguish between high and low nicotine doses; whereas, nicotine administration in the alcohol-dependent and stimulant-dependent groups resulted in opposite findings across a range of spectral bands.Conclusions:Although further research is warranted, these results may have implications for the study of smoking cessation and attentional functioning among substance abusers in treatment. These data suggest that nicotine-related changes in neurophysiology may be associated with specific brain areas and/or specific drug histories and reinforce the need for caution in generalizing among such groups.