A novel differential predict model based on matrix-assisted laser ionization time-of-flight mass spectrometry and serum ferritin for acute graft-versus-host disease.
A novel differential predict model based on matrix-assisted laser ionization time-of-flight mass spectrometry and serum ferritin for acute graft-versus-host disease.
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基于基质辅助激光电离飞行时间质谱和血清铁蛋白的急性移植物抗宿主病的新型差异预测模型
DOI：
10.1155/2013/563751
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发表时间：
2013
影响因子：
--
通讯作者：
Tian YP
中科院分区：
文献类型：
--
作者：
Zhang CY;Wang SH;Huang WR;Guo GH;Zhang ZH;Mou WJ;Yu L;Tian YP
急性移植物抗宿主病（acute graft-versus-host disease，aGVHD）的临床诊断主要依靠临床表现和组织活检，早期症状不明显时，往往延误诊断和治疗。本研究旨在探讨血清蛋白谱联合血清铁蛋白对异基因造血干细胞移植（allo-HSCT）前后aGVHD风险进行预警的可能性。采用免疫组织化学方法比较移植前后多肽表达的差异，同时检测血清铁蛋白水平。结合血清铁蛋白和质谱数据，本模型对移植前重度aGVHD（III~IV°aGVHD）的诊断敏感性和特异性均提高到90.0%，而移植后的敏感性和特异性分别为78.3%和86.4%。联合预警模型可以预测移植前后aGVHD尤其是重度aGVHD的发生风险，为患者病情的持续监测提供了可靠的方法。
Clinical diagnosis of acute graft-versus-host disease (aGVHD) mainly depends on clinical manifestation and tissue biopsies, leading to a delayed diagnosis and treatment for aGVHD patients when the early symptom is insignificant. Our objective was to investigate the possibility of prewarning the risk of aGVHD before and after allogeneic hematopoietic stem cell transplantation (allo-HSCT) by serum protein profiling combined with serum ferritin. The difference in polypeptide expression before and after transplantation had been compared by using CLINPROT technology, and serum ferritin levels have been analyzed simultaneously. Through combining serum ferritin and MS spectral data, the diagnosis sensitivity and specificity of our model for prewarning severe aGVHD (III~IV°aGVHD) before transplant all increased to 90.0%, while after transplant, the sensitivity and specificity are 78.3% and 86.4%. Our joint prewarning model could predict the risk of aGVHD, especially severe aGVHD before and after transplant, which also provides a reliable method to the continuous monitoring of the condition of patients.
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影响因子：
3.2
作者：
Perez L;Anasetti C;Pidala J
通讯作者：
Pidala J
DOI：
10.1158/1078-0432.ccr-10-1198
发表时间：
2011-01-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Tawara I;Koyama M;Liu C;Toubai T;Thomas D;Evers R;Chockley P;Nieves E;Sun Y;Lowler KP;Malter C;Nishimoto N;Hill GR;Reddy P
通讯作者：
Reddy P
影响因子：
20.3
作者：
Paczesny, Sophie;Krijanovski, Oleg I.;Ferrara, James L. M.
通讯作者：
Ferrara, James L. M.
影响因子：
2
作者：
Kaneshiro, Nagayuki;Xiang, Yang;Kato, Tomohiro
通讯作者：
Kato, Tomohiro
影响因子：
4.8
作者：
Kobbe, G;Schneider, P;Haas, R
通讯作者：
Haas, R