AMP-Activated Protein Kinase Potential Role in Cardiac Electrophysiology and Arrhythmias
AMP-Activated Protein Kinase Potential Role in Cardiac Electrophysiology and Arrhythmias
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DOI：
10.1161/circep.112.972265
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发表时间：
2012-08-01
影响因子：
8.4
通讯作者：
Nattel, Stanley
中科院分区：
文献类型：
--
作者：
Harada, Masahide;Nattel, Sarah Naomi;Nattel, Stanley
转化生长因子-β-活化激酶是丝裂原活化蛋白激酶激酶家族的成员，也参与AMPK活化。PPs，特别是PP 2A和PP 2C，通过使Thr-172去磷酸化来调节AMPK活性。AMP与γ-亚基的结合诱导α-亚基的构象变化，从而阻止PPs使AMPK去磷酸化。3
The transforming growth factor-β–activated kinase, a member of the mitogen-activated protein kinase kinase family, is also implicated in AMPK activation. 11 PPs, particularly PP2A and PP2C, regulate AMPK activity by dephosphorylating Thr-172. AMP binding to the γ-subunit induces a conformational change in the α-subunit that prevents AMPK dephosphorylation by PPs. 3