A FAMILY OF RELATED ATP-BINDING SUBUNITS COUPLED TO MANY DISTINCT BIOLOGICAL PROCESSES IN BACTERIA
A FAMILY OF RELATED ATP-BINDING SUBUNITS COUPLED TO MANY DISTINCT BIOLOGICAL PROCESSES IN BACTERIA
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DOI：
10.1038/323448a0
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发表时间：
1986-10-02
期刊：
影响因子：
64.8
通讯作者：
HERMODSON, MA
中科院分区：
文献类型：
--
作者：
HIGGINS, CF;HILES, ID;HERMODSON, MA
许多生物过程都与ATP水解有关。我们在这里描述了一类密切相关的atp结合蛋白，这些蛋白来自几种细菌物种，它们与多种细胞功能相关，包括膜运输、细胞分裂、根瘤菌结瘤和溶血素输出。这些蛋白质包括一个结构和功能相关的亚基家族，它们具有共同的进化起源，结合ATP，并可能将ATP水解偶联到这些生物过程中。这一发现表明ATP在细胞分裂、固氮过程中的结瘤和蛋白质输出中具有特定的作用，并使我们能够从这些系统中分配一种可能的功能给蛋白质成分。
Many biological processes are coupled to ATP hydrolysis. We describe here a class of closely related ATP-binding proteins, from several bacterial species, which are associated with a variety of cellular functions including membrane transport, cell division, nodulation inRhizobiumand haemolysin export. These proteins comprise a family of structurally and functionally related subunits which share a common evolutionary origin, bind ATP and probably serve to couple ATP hydrolysis to each of these biological processes. This finding suggests a specific role for ATP in cell division, nodulation during nitrogen fixation and protein export, and allows us to assign a probable function to one of the protein components from each of these systems.