Ambroxol Induces Autophagy and Potentiates Rifampin Antimycobacterial Activity
Ambroxol Induces Autophagy and Potentiates Rifampin Antimycobacterial Activity
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DOI：
10.1128/aac.01019-18
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发表时间：
2018-09-01
影响因子：
4.9
通讯作者：
Deretic, Vojo
中科院分区：
文献类型：
--
作者：
Choi, Seong Won;Gu, Yuexi;Deretic, Vojo
结核病的宿主导向治疗是针对结核分枝杆菌的抗生素化疗的潜在辅助治疗。氨溴索是一种先导化合物，它是从一种诱导自噬的药物中筛选出来的。在临床相关剂量下，氨溴索在体外和体内诱导自噬，并促进巨噬细胞中的分枝杆菌杀灭。氨溴索还在鼠结核病模型中增强利福平活性。
Host-directed therapy in tuberculosis is a potential adjunct to antibiotic chemotherapy directed at Mycobacterium tuberculosis. Ambroxol, a lead compound, emerged from a screen for autophagy-inducing drugs. At clinically relevant doses, ambroxol induced autophagy in vitro and in vivo and promoted mycobacterial killing in macrophages. Ambroxol also potentiated rifampin activity in a murine tuberculosis model.