Neurotoxic potential of ingested ZnO nanomaterials on bees
Neurotoxic potential of ingested ZnO nanomaterials on bees
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DOI：
10.1016/j.chemosphere.2014.07.054
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发表时间：
2015-02-01
期刊：
影响因子：
8.8
通讯作者：
Drobne, Damjana
中科院分区：
文献类型：
--
作者：
Milivojevic, Tamara;Glavan, Gordana;Drobne, Damjana
蜜蜂是最重要的传粉媒介之一，受到环境污染、害虫防治以及潜在的纳米技术产品的威胁。本研究的目的是分析摄入的氧化锌纳米材料 (ZnO NMs) 或锌离子 (Zn2+) 对蜜蜂的潜在神经毒性。我们分析了多种生物标志物，包括代谢障碍、进食率和存活率，以及应激相关酶谷胱甘肽 S-转移酶和神经毒性生物标志物乙酰胆碱酯酶的活性。发现暴露于任何一种测试物质的蜜蜂中乙酰胆碱酯酶活性升高。此外，我们观察到 Zn2+ 处理组的摄食率增加，但 ZnO NMs 或对照组的摄食率没有增加。我们观察到的效应主要与 Zn2+ 离子有关。在这里，我们提供的证据表明，源自锌盐或锌基纳米颗粒的锌离子具有潜在的神经毒性，因此可能有助于菌落存活。 (c) 2014 Elsevier Ltd. 保留所有权利。
The honey bee is among most important pollinators threatened by environmental pollution, pest control and potentially, by products of nanotechnologies. The aim of the current study was an analysis of the neurotoxic potential of ingested zinc oxide nanomaterials (ZnO NMs) or zinc ions (Zn2+) on honey bees. We analysed a variety of biomarkers, including metabolic impairment, feeding rate, and survival, as well as the activities of a stress-related enzyme glutathione S-transferase, and the neurotoxicity biomarker acetylcholinesterase. Acetylcholinesterase activity was found to be elevated in bees exposed to either of the tested substances. In addition, we observed increased feeding rate in the group treated with Zn2+ but not with ZnO NMs or control group. The observed effects we relate primarily to Zn2+ ions. Here we provide evidence that zinc ions either originating from Zn salt or Zn-based NPs have a neurotoxic potential and thus might contribute to colony survival. (c) 2014 Elsevier Ltd. All rights reserved.