Parasite polymorphism may serve to enhance fitness in different host environments.
Parasite polymorphism may serve to enhance fitness in different host environments.
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寄生虫多态性可能有助于增强不同宿主环境的适应性。
DOI：
10.1089/153036602760260751
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发表时间：
2002
期刊：
影响因子：
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通讯作者：
Pereira,MiercioEA
中科院分区：
文献类型：
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作者：
Takano-Lee,Miwako;Edman,JohnD;Herrera,EnriqueM;Tussie-Luna,MariaI;Pereira,MiercioEA
克氏锥虫（Silvio菌株）的反式唾液酸酶（TS）表型表达仅限于宽型锥虫（TS+寄生虫）的一个亚群（20-30%），而细长型锥虫的较大亚群缺乏TS表达（TS-寄生虫）。研究结果表明，长尾若虫感染了分离型t病毒。cruziparasite种群（Silvio菌株）。摄入TS-寄生虫的昆虫产生的寄生虫负荷明显高于摄入TS+寄生虫或未分离种群的昆虫。在TS+群体中添加1.0μg /ml的TS单克隆抗体（TCN-2），使TS+群体的寄生虫数量增加到与TS群体相当的水平。相比之下，在TS-parasite血餐中添加外源TS可显著降低寄生虫负荷，其水平与摄入TS+寄生虫相当。这些结果表明，t。Cruzitrypomastigote多态性可能有助于提高不同寄主环境下的存活率。
Phenotypic expression oftrans-sialidase (TS) byTrypanosoma cruzi(Silvio strain) is restricted to a subpopulation (20-30%) of broad trypomastigotes (TS+parasites), while the larger subpopulation of slender trypomastigotes lacks TS expression (TS-parasites).Rhodnius prolixusnymphs were infected with fractionatedT. cruziparasite populations (Silvio strain). Bugs ingesting TS-parasites produced significantly higher parasite loads than bugs ingesting either TS+parasites or unfractionated populations. The addition of 1.0μg of TS monoclonal antibody (TCN-2)/ml of blood meal to TS+populations increased parasite populations to levels comparable to those of TS populations. In contrast, the addition of exogenous TS to TS-parasite blood meals significantly reduced parasite loads to levels comparable to bugs ingesting TS+parasites. These results suggest thatT. cruzitrypomastigote polymorphism may serve to enhance survival in different host environments.