T lymphocyte clones illuminate pathogenesis and affect therapy of experimental arthritis.
T lymphocyte clones illuminate pathogenesis and affect therapy of experimental arthritis.
复制标题
T 淋巴细胞克隆阐明了发病机制并影响实验性关节炎的治疗。
DOI：
10.1002/art.1780280802
复制
发表时间：
1985
影响因子：
--
通讯作者：
Frenkel,A
中科院分区：
文献类型：
--
作者：
Cohen,IR;Holoshitz,J;vanEden,W;Frenkel,A
我们最近对佐剂性关节炎的发病机制和操作的研究是基于介导、预防或治疗关节炎的T淋巴细胞的长期系和克隆。在疾病中发挥功能的T淋巴细胞系的发展是一项技术进步，它为佐剂性关节炎的3个方面带来了新的认识：其病因，发病机制和治疗。我们相信这种动物模型的研究提供了可能对一般的流变学有用的工具和概念。佐剂性关节炎最初是一种亚急性炎症，然后发展为慢性多发性关节炎; 30年前，Pearson首次描述了这种情况（1）。通过向遗传易感大鼠注射油中的结核分枝杆菌（Mt）（一种称为弗氏完全佐剂（FCA）的材料），可诱导遗传易感大鼠（2）发生该疾病。注射后约11-13天出现的关节炎在四肢小关节中突出，其特征为滑膜炎症、血管翳形成、软骨破坏和骨侵蚀（3）。急性
Our recent studies of the pathogenesis and manipulation of adjuvant arthritis are based on longterm lines and clones of T lymphocytes that mediate, prevent, or treat arthritis. The development of lines of T lymphocytes that are functional in disease is a technological advance that has cast new light on 3 aspects of adjuvant arthritis: its etiology, pathogenesis, and treatment. We believe this investigation of the animal model provides both tools and concepts that may be useful for rheumatology in general. Adjuvant arthritis begins as a subacute inflammation that progresses to a chronic polyarthritis; it was first described 3 decades ago by Pearson (1). The disease is inducible in genetically susceptible rats (2) by injecting them with Mycobacterium tuberculosis (Mt) in oil, a material known as Freund’s complete adjuvant (FCA). The arthritis, which appears about 11-13 days after injection, is prominent in the small joints of the extremities and is characterized by inflammation of the synovium, formation of pannus, destruction of cartilage, and erosion of bone (3). Acute