Nocturnal proinflammatory cytokine-associated sleep disturbances in abstinent African American alcoholics
Nocturnal proinflammatory cytokine-associated sleep disturbances in abstinent African American alcoholics
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DOI：
10.1016/j.bbi.2004.02.001
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发表时间：
2004-07-01
影响因子：
15.1
通讯作者：
Ehlers, C
中科院分区：
文献类型：
--
作者：
Irwin, M;Rinetti, G;Ehlers, C
动物研究表明，细胞因子在睡眠调节中起着关键作用。酒精中毒患者表现出严重的睡眠改变和睡眠丧失后睡眠的自我平衡恢复缺陷。在这项研究中，我们调查了夜间血浆白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF）水平是否与酒精依赖性睡眠障碍相关，通过测试这些炎性细胞因子和睡眠之间的时间关系，睡眠剥夺前后。在戒酒的非裔美国人酗酒者（n = 16）和匹配的对照组（n = 15）中，在基线、部分睡眠剥夺和恢复夜进行整夜多导睡眠描记术和23：00、03：00和06：30 h连续采血。再加上睡眠潜伏期延长和快速眼动睡眠增加，酗酒者显示夜间升高的IL-6和TNF相比，控制酒精消费量和体重指数调整后。睡眠剥夺后，酗酒者表现出更大的夜间水平的IL-6和更大的夜间增加的TNF相比，控制。调整潜在混杂因素后，23：00时的睡前IL-6水平与睡眠潜伏期延长相关，而03：00时的IL-6水平与后半夜的快速眼动睡眠相关。总之，这些发现表明，促炎细胞因子的循环水平可能对睡眠启动有负面影响。这些发现对于确定酗酒者睡眠紊乱的原因具有重要意义，并可能有助于开发新的治疗方法来优化这一人群的睡眠。(C)2004年爱思唯尔公司All rights reserved.
Animal studies reveal that cytokines play a key role in the regulation of sleep. Alcoholic patients show profound alterations of sleep and a defect in the homeostatic recovery of sleep following sleep loss. In this study, we investigated whether nocturnal plasma levels of interieukin-6 (IL-6) and tumor necrosis factor-alpha (TNF) were associated with disordered sleep in alcohol dependence by testing the temporal relationships between these inflammatory cytokines and sleep, before and after sleep deprivation. All-night polysomnography and serial blood sampling at 23:00, 03:00, and 06:30 h were conducted across baseline, partial sleep deprivation, and recovery nights in abstinent African American alcoholics (n = 16) and matched controls (n = 15). Coupled with prolonged sleep latency and increased rapid eye movement sleep, alcoholics showed nocturnal elevations of IL-6 and TNF as compared to controls after adjustment for alcohol consumption and body mass index. Following sleep deprivation, alcoholics showed greater nocturnal levels of IL-6 and greater nocturnal increases of TNF as compared to controls. Pre-sleep IL-6 levels at 23:00 h correlated with prolonged sleep latency after adjustment for potential confounders whereas IL-6 levels at 03:00 It correlated with rapid eye movement sleep in the second half of the night. Taken together, these findings indicate that circulating levels of proinflammatory cytokines may have a negative influence on sleep initiation. These findings have implications for determining why sleep is disordered in alcoholics and may aid in the development of novel treatments to optimize sleep in this population. (C) 2004 Elsevier Inc. All rights reserved.