Age-Specific Seroprevalences of Merkel Cell Polyomavirus, Human Polyomaviruses 6, 7, and 9, and Trichodysplasia Spinulosa-Associated Polyomavirus
Age-Specific Seroprevalences of Merkel Cell Polyomavirus, Human Polyomaviruses 6, 7, and 9, and Trichodysplasia Spinulosa-Associated Polyomavirus
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DOI：
10.1128/cvi.00438-12
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发表时间：
2013-03-01
影响因子：
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通讯作者：
Coursaget, Pierre
中科院分区：
文献类型：
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作者：
Nicol, Jerome T. J.;Robinot, Remy;Coursaget, Pierre
自2008年以来，已经发现了6种新的人类多瘤病毒（默克尔细胞多瘤病毒[MCPyV]、人类多瘤病毒6 [HPyV6]、HPyV7、HPyV9、棘毛不发育多瘤病毒[TSPyV]和马拉维多瘤病毒[MWPyV]）。采用病毒样颗粒酶联免疫吸附试验（elisa）对828名年龄在1至100岁的意大利受试者进行了MCPyV、HPyV6、HPyV7、HPyV9和TSPyV特异性抗体的检测。研究结果表明，所有这些新型多瘤病毒在人类中广泛流行，成年期HPyV9的血清患病率从39.4%到MCPyV的87.1%不等，除了HPyV7和HPyV9，它们的血清患病率在整个生命过程中都在增加外，初次暴露在儿童时期最为强烈。高抗体滴度的受试者比例随着MCPyV的年龄而增加，而随着TSPyV的年龄而减少。
Six new human polyomaviruses have been identified since 2008 (Merkel cell polyomavirus [MCPyV], human polyomavirus 6 [HPyV6], HPyV7, HPyV9, trichodysplasia spinulosa polyomavirus [TSPyV], and Malawi polyomavirus [MWPyV]). The presence of specific antibodies against MCPyV, HPyV6, HPyV7, HPyV9, and TSPyV in 828 Italian subjects aged 1 to 100 years was investigated by virus-like particle-based enzyme-linked immunosorbent assays (ELISAs). The findings indicate that all of these new polyomaviruses circulate widely in humans, with seroprevalences in adulthood ranging from 39.4% for HPyV9 to 87.1% for MCPyV, and that primary exposure is most intense in childhood, with the exception of HPyV7 and HPyV9, for which the sero-prevalence increased throughout life. The proportion of subjects with high antibody titers was found to increase with age for MCPyV and to decrease with age for TSPyV.