GANGLIOSIDES OF HUMAN SPINAL-CORD - ABERRANT COMPOSITION OF CORDS FROM PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS
GANGLIOSIDES OF HUMAN SPINAL-CORD - ABERRANT COMPOSITION OF CORDS FROM PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS
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DOI：
10.1002/jnr.490120209
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发表时间：
1984-01-01
影响因子：
4.2
通讯作者：
STEFANSSON, K
中科院分区：
文献类型：
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作者：
DAWSON, G;STEFANSSON, K
福尔马林固定的人脊髓和新鲜的人脊髓的神经节苷脂含量被认为是定量和定性相似。脊髓的神经节苷脂含量是不均匀的。特别是，观察到GD1a的梯度，从颈部区域的低含量增加到骶骨区域的相对高含量。比较9个正常脊髓和9个临床诊断的肌萎缩侧索硬化症（ALS）患者脊髓的神经节苷脂含量，发现没有重大的定量差异，但ALS脊髓中3个额外的神经节苷脂的独特存在。其中一种被初步鉴定为唾液酸globotetraosylceramide，并且在9个对照脊髓样品中的8个中不存在，唯一的例外是来自97岁女性的脊髓。
The ganglioside content of formalin-fixed human spinal cords and fresh human spinal cords was found to be both quantitatively and qualitatively similar. The spinal cord was heterogeneous with respect to ganglioside content. In particular, a gradient of GD1a was observed, increasing from a low content in the cervical region to a relatively high content in the sacral region. Comparison of the ganglioside content of 9 normal spinal cords and 9 spinal cords from clinically diagnosed amyotrophic lateral sclerosis (ALS) patients revealed no major quantitative differences, but the unique presence of 3 additional gangliosides in ALS spinal cords. One of these was tentatively identified as sialosylglobotetraosylceramide and was absent from 8 of 9 control spinal cord samples, the sole exception being the cord from a 97-yr-old female.