High-volume continuous venovenous hemodiafiltration plus resin hemoperfusion improves severe metformin-associated toxicity
High-volume continuous venovenous hemodiafiltration plus resin hemoperfusion improves severe metformin-associated toxicity
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DOI：
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发表时间：
2017
影响因子：
3.2
通讯作者：
Wei Shi
中科院分区：
文献类型：
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作者：
Shuangxin Liu;Lixia Xu;Jianchao Ma;Renwei Huang;Ting Lin;Zhuo Li;Huabang Liang;Houqin Xiao;Xinling Liang;Wei Shi
We present the case of a 42-year-old female patient who attempted suicide by taking approximately 100 tablets of metformin (500 mg). Laboratory tests revealed severe lactic acidosis with lactate levels of 24 mmol/L and pH of 7.09. The patient was treated with high-volume continuous venovenous hemodiafiltration (CVVH) and resin-sorbent hemop-erfusion. Metformin concentrations were measured by high-performance liquid chro-matography during CVVH and hemoperfusion treatment. Before extracorporeal treatment, he plasma metformin concentration was 208.5 mg/L. After CVVH treatment for 24 h, the.plasma metformin concentration had decreased to 13.9 mg/L. Resin-based sorbent hemoperfusion plus CVVH treatment had reduced the metformin plasma concentration by 61.8% after 3 h. After 7 days, the patient’s laboratory tests and clinical syndrome were improved, and she was discharged from hospital. We provide evidence that CVVH plus hemoperfusion is effective in eliminating metformins and metabolic products.
