Brain-Derived Neurotrophic Factor Predicts Mortality Risk in Older Women
Brain-Derived Neurotrophic Factor Predicts Mortality Risk in Older Women
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DOI：
10.1111/j.1532-5415.2009.02345.x
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发表时间：
2009-08-01
影响因子：
6.3
通讯作者：
Bruunsgaard, Helle
中科院分区：
文献类型：
--
作者：
Krabbe, Karen S.;Mortensen, Erik L.;Bruunsgaard, Helle
目的验证低循环脑源性神经营养因子（BDNF）预测85岁男性和女性全因死亡风险的假设。BDNF是神经营养因子家族的一种分泌性成员，在神经变性和应激反应中具有保护作用，并在代谢中具有调节作用。设计纵向研究，随访50- 58个月。1914队列是由格洛斯特鲁普医院预防和健康研究中心于1964年建立的以人群为基础的队列。参与者：188名未被选中的85岁丹麦人。测定血浆和血清中sbdnf的含量。使用丹麦国家患者登记册收集发病率数据。Cox回归分析的主要结局是全因死亡率。结果血浆BDNF低（最低胎位）的妇女比血浆BDNF高（最高胎位）的妇女有更高的全因死亡风险（风险比=2.2,95%可信区间=1.1-4.7）。低血浆BDNF预测死亡率独立于日常生活活动；教育;有中枢神经系统疾病、脑血管意外、心血管疾病、癌症、呼吸系统疾病和低度炎症病史。血浆BDNF与男性死亡率之间未发现关联，血清BDNF对男女死亡率均无影响。结论低血浆BDNF是一种新的、独立的、可靠的老年妇女死亡风险生物标志物。BDNF可能是老年人群多重发病网络的中心因素。
OBJECTIVESTo test the hypothesis that low circulating brain-derived neurotrophic factor (BDNF), a secretory member of the neurotrophin family that has a protective role in neurodegeneration and stress responses and a regulatory role in metabolism, predicts risk of all-cause mortality in 85-year-old men and women.DESIGNLongitudinal study with 50- to 58-month follow-up.SETTINGThe 1914 cohort, a population-based cohort established in 1964 by the Research Center for Prevention and Health at Glostrup Hospital.PARTICIPANTSOne hundred eighty-eight unselected 85-year-old Danes.MEASUREMENTSBDNF was measured in plasma and serum. The Danish National Register of Patients was used to collect data on morbidity. The primary outcome in Cox regression analyses was all-cause mortality.RESULTSWomen with low plasma BDNF (lowest tertile) had greater all-cause mortality risk than women with high plasma BDNF (highest tertile) (hazard ratio=2.2, 95% confidence interval=1.1-4.7). Low plasma BDNF predicted mortality independently of activities of daily living; education; and a history of central nervous system disease, cerebrovascular accidents, cardiovascular disease, cancer, respiratory disease, and low-grade inflammation. No association was found between plasma BDNF and mortality in men, and serum BDNF did not influence mortality in either sex.CONCLUSIONLow plasma BDNF is a novel, independent, and robust biomarker of mortality risk in old women. BDNF may be a central factor in the network of multimorbidity in old populations.