Activation of inspiratory muscles via spinal cord stimulation.

Activation of inspiratory muscles via spinal cord stimulation.
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DOI:
10.1016/j.resp.2013.06.001
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发表时间:
2013-11-01
影响因子:
2.3
通讯作者:
Kowalski, Krzysztof E.
Kowalski, Krzysztof E.
中科院分区:
医学4区
文献类型:
--
作者:
DiMarco, Anthony F.;Kowalski, Krzysztof E.

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膈肌起搏是一种临床上有用的方式,为呼吸机依赖性脊髓损伤患者提供人工呼吸支持。由于该技术仅在约50%的患者中成功地提供了全时的辅助支持,因此需要更好的方法。在本文中,我们回顾了一种新的方法,吸气肌激活涉及应用电刺激施加到腹侧表面的上胸脊髓在高刺激频率(300 Hz)。在动物模型中,高频脊髓刺激(HF-SCS)导致膈肌和吸气肋间肌的同步激活。由于这种方法导致EMG活动的异步模式和平均峰值放电频率与自主呼吸期间观察到的相似,因此HF-SCS是一种更具生理性的吸气肌肉激活形式。此外,可以在低刺激幅度(<1 mA)下通过重复刺激长期维持通气。这些初步结果表明,HF-SCS有望成为一种更成功的吸气肌起搏方法。
Diaphragm pacing is a clinically useful modality providing artificial ventilatory support in patients with ventilator dependent spinal cord injury. Since this technique is successful in providing full-time ventilatory support in only ~50% of patients, better methods are needed. In this paper, we review a novel method of inspiratory muscle activation involving the application of electrical stimulation applied to the ventral surface of the upper thoracic spinal cord at high stimulus frequencies (300 Hz). In an animal model, high frequency spinal cord stimulation (HF-SCS) results in synchronous activation of both the diaphragm and inspiratory intercostal muscles. Since this method results in an asynchronous pattern of EMG activity and mean peak firing frequencies similar to those observed during spontaneous breathing, HF-SCS is a more physiologic form of inspiratory muscle activation. Further, ventilation can be maintained on a long-term basis with repetitive stimulation at low stimulus amplitudes (<1 mA). These preliminary results suggest that HF-SCS holds promise as a more successful method of inspiratory muscle pacing.
DOI: 10.1152/japplphysiol.00628.2003
发表时间: 2004-06-01
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作者:
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期刊: AMERICAN REVIEW OF RESPIRATORY DISEASE
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