Patterns of stress in schizophrenia
Patterns of stress in schizophrenia
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DOI：
10.1016/j.psychres.2007.06.001
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发表时间：
2008-07-15
影响因子：
11.3
通讯作者：
Szeszko, Philip R.
中科院分区：
文献类型：
--
作者：
Betensky, Julia D.;Robinson, Delbert G.;Szeszko, Philip R.
虽然人们普遍认为压力在精神分裂症的病理生理学中起着关键作用，但对患者经历的特定类型的压力知之甚少。关于压力事件、人格中介和情绪反应之间的相互作用，人们知之甚少。本研究采用Derogatis应激量表（DSP）对29例精神分裂症患者和36名健康志愿者的10个应激维度进行了调查，并探讨了这些维度与患者症状的关系。总体而言，与健康志愿者相比，患者的压力增加了约0.75个标准差。与健康志愿者相比，患者的压力显着增加，特别是在与家庭环境，驱动行为和抑郁相关的领域，但在健康，态度姿势，时间压力，放松潜力，角色定义，敌意或焦虑方面没有观察到。患者中DSP评定的抑郁与更大的阴性症状严重程度显著相关。抗精神病药物暴露时间较短的患者比暴露时间较长的患者有更大的敌意，但在任何其他方面没有差异。对家庭环境压力源、驱动行为和抑郁症的持续调查可能有助于识别高危人群，并有助于了解已诊断为精神分裂症的患者的症状加重和复发诱因。(C)2007爱思唯尔爱尔兰有限公司保留所有权利。
Although it is widely recognized that stress plays a key role in the pathophysiology of schizophrenia, little is known regarding the particular types of stress patients experience. Less is known about the interplay among stressful events, personality mediators, and emotional responses. In this study, we investigated 10 stress dimensions in 29 patients with schizophrenia and 36 healthy volunteers using the Derogatis Stress Profile (DSP), and the relationship between these dimensions and symptoms in patients. Overall, patients had an approximate 0.75 standard deviation increase in stress compared with healthy volunteers. Significant increases in stress among patients compared with healthy volunteers were observed specifically in areas related to domestic environment, driven behavior, and depression, but not in health, attitude posture, time pressure, relaxation potential, role definition, hostility, or anxiety. More DSP-rated depression among patients correlated significantly with greater negative symptom severity. Patients with a shorter duration of antipsychotic drug exposure had significantly greater hostility than did patients with a longer duration of exposure, but did not differ in any other dimension. Continued investigation of domestic environmental stressors, driven behavior, and depression may be useful in identifying high-risk groups, and understanding symptom exacerbation and precipitants of relapse in patients already diagnosed with schizophrenia. (C) 2007 Elsevier Ireland Ltd. All rights reserved.