Roles of IL-17, Th1, and Tc1 cells in patients with IgG4-related sclerosing sialadenitis
Roles of IL-17, Th1, and Tc1 cells in patients with IgG4-related sclerosing sialadenitis
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DOI：
10.1002/lary.23429
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发表时间：
2012-10-01
期刊：
影响因子：
2.6
通讯作者：
Aoyagi, Masaru
中科院分区：
文献类型：
--
作者：
Ohta, Nobuo;Makihara, Seiichiro;Aoyagi, Masaru
目的/假设：免疫球蛋白 G4 (IgG4) 相关的硬化性唾液腺炎是最近公认的一种疾病实体，其特征是高血清 IgG4 浓度和受影响器官中产生 IgG4 的浆细胞扩张，显示纤维化或硬化变化。然而，人们对 CD4+ 和 CD8+ T 细胞或白细胞介素 (IL)-17 在这种疾病中的作用知之甚少。本研究的目的是评估 IgG4 相关的硬化性唾液腺炎患者的 CD4+ 和 CD8+ T 细胞以及 IL-17 的特征。研究设计：山形大学医学院的一项回顾性临床研究。方法：患者组由男6例、女4例组成，年龄38～73岁，平均57.9岁。使用细胞内细胞因子流式细胞术检查来自 IgG4 相关硬化性唾液腺炎患者的 T 辅助细胞 (Th)1、Th2、T 细胞毒性型 (Tc)1 和 Tc2 细胞亚群。还通过免疫组织化学方法研究了患者病变中 IL-17 的表达。结果：6 例 IgG4 相关性硬化性涎腺炎患者，其 IgG4/IgG 比值高，受累唾液腺 IgG4 阳性浆细胞明显浸润，在唾液腺初始肿胀后出现全身并发症，包括胰腺炎、腹膜后纤维化和/或肺部炎性假瘤。 IgG4 相关的硬化性唾液腺炎中的 Th1 和 Tc1 细胞数量显着高于对照组 (P < .05)，但 Th2 和 Tc2 细胞数量没有显着增加。在受影响患者的皮损中观察到 IL-17 的表达。结论：Th1和Tc1细胞群及IL-17表达增加可能参与IgG4相关硬化性唾液腺炎的发病机制。喉镜, 2012
Objectives/Hypothesis: Immunoglobulin G4 (IgG4)-related sclerosing sialadenitis is a recently recognized disease entity characterized by high serum IgG4 concentration and IgG4-producing plasma cell expansion in affected organs, which show fibrotic or sclerotic changes. However, little is known about the roles of CD4+ and CD8+ T cells or interleukin (IL)-17 in this disease. The purpose of this study was to evaluate the characteristics of CD4+ and CD8+ T cells and IL-17 in patients with IgG4-related sclerosing sialadenitis. Study Design: A retrospective clinical study at the Yamagata University School of Medicine. Methods: The patient group consisted of six males and four females with an average age of 57.9 years (range, 38 to 73years). Subsets of T helper (Th)1, Th2, T cytotoxic type (Tc)1, and Tc2 cells from patients with IgG4-related sclerosing sialadenitis were examined by using intracellular cytokine flow cytometry. Expression of IL-17 in the patients' lesions was also investigated immunohistochemically. Results: Six patients with IgG4-related sclerosing sialadenitis with high ratios of IgG4/IgG and prominent infiltration of IgG4-positive plasmacytes in the involved salivary glands had systemic complications, including pancreatitis, retroperitoneal fibrosis, and/or inflammatory pseudotumor of the lung after the initial swelling of the salivary glands. Populations of Th1 and Tc1 cells were significantly greater in IgG4-related sclerosing sialadenitis than in the controls (P < .05), but Th2 and Tc2 cell populations were not significantly increased. Expression of IL-17 was observed in the lesions of affected patients. Conclusions: Increases in Th1 and Tc1 cell populations and IL-17 expression might be involved in the mechanism of pathogenesis of IgG4-related sclerosing sialadenitis. Laryngoscope, 2012