Impaired control of renal hemodynamics and renin release during hyperkalemia in rabbits.
Impaired control of renal hemodynamics and renin release during hyperkalemia in rabbits.
复制标题
兔高钾血症期间肾血流动力学和肾素释放的控制受损。
DOI：
10.1152/ajprenal.1988.254.5.f704
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Young,DB
中科院分区：
文献类型：
--
作者：
Lin,HB;Young,DB
我们分析了高钾血症对兔肾血流动力学控制和肾素释放的影响。通过静脉输注氯化钾，血浆钾活性维持在可控的升高水平。对照组（n = 23）的钾活性平均为3.20 +/- 0.06 meq/l，高钾血症组（n = 13）的钾活性平均为5.80 +/- 0.13 meq/l。肾血流（RBF）、肾小球滤过率（GFR）和肾素释放在肾上主动脉收缩达到的肾灌注压力范围内测量。对照组RBF和GFR在100 ~ 80 mmHg范围内表现出良好的自我调节能力。然而，在高钾血症组中，自我调节功能明显受损。在100 mmHg时，高钾血症组的RBF和GFR平均分别比对照组高33%和34% (P < 0.005)；在自动调节范围（100-80 mmHg）内，高钾血症组的这两个变量均大于对照组。两组肾素释放值在100毫米汞柱压力水平下无差异，高钾血症组肾素释放随灌注压力降低而升高，高于对照组。在70和60毫米汞柱水平下，高钾血症组肾素释放平均比对照组高300% （P < 0.05）。然而，当以百分比变化表示时，高钾血症的刺激作用不明显。（摘要删节250字）
We analyzed the changes in control of renal hemodynamics and renin release resulting from hyperkalemia in the rabbit. Plasma potassium activity was maintained at a controlled elevated level by intravenous infusion of KCl. The potassium activity of the control group (n = 23) averaged 3.20 +/- 0.06 meq/l and that of the hyperkalemic group (n = 13) averaged 5.80 +/- 0.13 meq/l. Renal blood flow (RBF), glomerular filtration rate (GFR), and renin release were measured over a range of renal perfusion pressures achieved by constriction of the suprarenal aorta. The control group's RBF and GFR exhibited excellent autoregulatory capability from 100 to 80 mmHg. However, significant impairment of autoregulation was apparent in the hyperkalemic group. At 100 mmHg, RBF and GFR in the hyperkalemic group averaged 33 and 34% greater, respectively, than those of the control group (P less than 0.005); both variables in the hyperkalemic group were greater than the values of the control group over the autoregulatory range (100-80 mmHg). The renin release values for the two groups were not different at the 100-mmHg pressure level, although renin release of the hyperkalemic group increased to higher levels than those of the control group as perfusion pressure was reduced. At the 70- and 60-mmHg levels renin release from the hyperkalemic group averaged approximately 300% greater than that of the control group (P less than 0.05). However, when expressed as percentage change, the stimulatory effect of hyperkalemia was not apparent.(ABSTRACT TRUNCATED AT 250 WORDS)