Complement activation during cardiopulmonary bypass in children.
Complement activation during cardiopulmonary bypass in children.
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儿童体外循环期间的补体激活。
DOI：
10.1159/000463031
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
M. Leijala
中科院分区：
文献类型：
--
作者：
S. Meri;M. Aronen;M. Leijala
对30例接受体外循环手术的儿童的血清和血浆样本进行前瞻性补体激活评估。每例患者的总溶血性C水平降低，C3活化产物（C3 a desArg和C3 bi/c）水平升高。在30例患者中，11例患者的手术与并发症相关：死亡（2例）、呼吸衰竭（RF，9例）、败血症（4例）、心包切开术后综合征（PPS，1例）和胰腺炎（1例）。患有RF的患者更年轻，经历了更长的灌注，并且在C系统中有更广泛的变化，尽管高C3 a desArg水平和RF之间没有直接的相关性。相反，C3 a desArg的增加与灌注时间呈线性相关。术后后期的大多数并发症与明显的低级别C激活事件相关。
Complement activation was evaluated prospectively in serial serum and plasma samples from 30 children, who underwent cardiopulmonary bypass operations. Each patient showed a decrease in total hemolytic C levels and increase in C3 activation product (C3a desArg and C3bi/c) levels. In 11 of the 30 patients surgery was associated with a complication: death (2), respiratory failure (RF, 9), septicaemia (4), postpericardiotomy syndrome (PPS, 1) and pancreatitis (1). Patients suffering from RF were younger, underwent longer perfusions and had somewhat more extensive changes in the C system, although no direct correlation between high C3a desArg levels and RF existed. Instead, the increase in C3a desArg was in linear correlation with the perfusion time. Most complications during the latter postoperative period were associated with distinct episodes of lower grade C activation.