Perfluorooctanoate and perfluorooctane sulfonate in umbilical cord blood and child cognitive development: Hamamatsu Birth Cohort for Mothers and Children (HBC Study)
Perfluorooctanoate and perfluorooctane sulfonate in umbilical cord blood and child cognitive development: Hamamatsu Birth Cohort for Mothers and Children (HBC Study)
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DOI：
10.1016/j.envint.2022.107215
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发表时间：
2022-05-01
影响因子：
11.8
通讯作者：
Tsuchiya, Kenji J.
中科院分区：
文献类型：
--
作者：
Oh, Jiwon;Shin, Hyeong-Moo;Tsuchiya, Kenji J.
背景：产前暴露于全氟烷基物质和多氟烷基物质(PFAS)已被证明会影响实验动物的子代行为。几项流行病学研究调查了产前接触PFAS与儿童神经发育之间的关系，但结果并不确定。我们研究了脐带血中全氟辛酸(PFOA)和全氟辛烷磺酸(PFOS)浓度与4至40个月大儿童认知发育的关系。方法：这项研究包括598对母亲和孩子，他们参加了日本一项前瞻性出生队列研究--滨松母子出生队列研究(HBC研究)。脐带血中的全氟辛烷磺酸和全氟辛烷磺酸进行了定量。在4、6、10、14、18、24、32和40个月时采用马伦早期学习量表(MSEL)评估儿童的认知功能。对于每一个log2转换的全氟辛烷磺酸和全氟辛烷磺酸浓度，我们检验了：1)在每个评估时间点与MSEL早期学习综合(综合)和四个分量表(精细运动、视觉接受、接受性语言、表达语言)的分数的相关性；以及2)综合和分量表分数的纵向变化的相关性。结果：在18个月龄时，MSEL综合评分与全氟辛酸呈负相关(每增加2倍浓度：β=-2.23，95%可信区间：-3.91，-0.56)，而在其他年龄段则不相关。考虑到从4个月到40个月的分数变化，全氟辛烷磺酸和全氟辛烷磺酸与综合语言得分以及接受性和表现性语言得分呈正相关。在14个月、18个月和40个月时，全氟辛烷磺酸与综合得分之间以及在14个月时全氟辛烷磺酸与综合得分之间的关联经性别修正后，在女性中显示出负关联。结论：在本研究中，脐血全氟辛烷磺酸和全氟辛烷磺酸浓度与特定年龄的儿童认知功能呈混合关系，但与4至40个月龄认知发育的纵向变化呈正相关。
Background: Prenatal exposure to per-and polyfluoroalkyl substances (PFAS) has been shown to affect offspring behaviors in laboratory animals. Several epidemiological studies investigated associations between prenatal PFAS exposure and child neurodevelopment, but results were inconclusive. We examined associations between cord blood concentrations of perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) and cognitive development in children from 4 to 40 months of age. Methods: This study included 598 mother & ndash;child pairs who participated in the Hamamatsu Birth Cohort Study for Mothers and Children (HBC Study), a prospective birth cohort study in Japan. PFOA and PFOS were quantified in cord blood. The Mullen Scales of Early Learning (MSEL) was used to assess child cognitive function at 4, 6, 10, 14, 18, 24, 32, and 40 months of age. For each of log 2-transformed PFOA and PFOS concentrations, we examined: 1) associations with the scores of MSEL Early Learning Composite (Composite) and four subscales (Fine Motor, Visual Reception, Receptive Language, Expressive Language) at each assessment time point; and 2) associations with longitudinal changes in the Composite and subscale scores. Results: MSEL Composite scores were inversely associated with PFOA at 18 months of age (per 2-fold increase in concentration: beta =-2.23, 95% CI:-3.91,-0.56), but not at other ages. When accounting for changes in scores from 4 to 40 months of age, PFOA and PFOS were positively associated with Composite as well as Receptive and Expressive Language scores. Child's sex modified associations between PFOA and Composite scores at 14, 18, and 40 months and those between PFOS and Composite scores at 14 months, showing negative associations among females. Conclusions: In this study, cord blood PFOA and PFOS concentrations showed mixed associations with child cognitive functions at specific age but had positive associations with longitudinal changes in cognitive devel-opment from 4 to 40 months of age.