Regulators of tissue destruction and homeostasis as diagnostic aids in periodontology
Regulators of tissue destruction and homeostasis as diagnostic aids in periodontology
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DOI：
10.1034/j.1600-0757.2000.2240110.x
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发表时间：
2000-01-01
影响因子：
18.6
通讯作者：
Kinane, DF
中科院分区：
文献类型：
--
作者：
Kinane, DF
现代临床和基础科学研究改变了我们对牙周病进展的范式。最近的许多研究都旨在通过基于宿主的测试来改进牙周诊断过程，这些测试利用了目前对疾病过程的进展和病理生理学的了解(38)。长期目标是，牙周病的治疗和预防将建立在基于病因因素的诊断测试基础上，而不仅仅是临床经验。基于基质金属蛋白酶或其抑制物的诊断试剂盒在这方面可能是至关重要的。本章讨论了基质金属蛋白酶家族在牙周病发病机制中的重要性，并重点讨论了基质金属蛋白酶及其组织抑制物检测的可能候选者，有临床数据表明它们具有潜在的实用价值。
Modern clinical and basic scientific research has changed our paradigms of the progression of periodontal disease. Many recent studies have been designed to improve periodontal diagnostic processes via host-based tests that utilize current understanding of the progression and pathophysiology of the disease process (38). The long-term aim is that treatment and prevention of periodontal disease will be founded on diagnostic tests based on etiopathogenic factors rather than just clinical experience. Diagnostic test kits based on matrix metalloproteinases or their inhibitors may be crucial in this respect. This chapter discusses the importance of the matrix metalloproteinase family in the pathogenesis of periodontal disease and focuses on likely candidates for matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase tests for which there is clinical data indicating their potential utility.