6-Mercaptopurine-induced alterations in mineral metabolism and teratogenesis in the rat.
6-Mercaptopurine-induced alterations in mineral metabolism and teratogenesis in the rat.
复制标题
6-巯基嘌呤诱导大鼠矿物质代谢和致畸的改变。
DOI：
10.1002/tera.1420340312
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Hurley,LS
中科院分区：
文献类型：
--
作者：
Amemiya,K;Keen,CL;Hurley,LS
研究了 6-巯基嘌呤引起的矿物质代谢改变与药物致畸作用之间的关系。怀孕的 Sprague-Dawley 大鼠的饮食中每 1 g 饮食含有 4.5、100 或 1,000 μg Zn。妊娠第11天，母鼠腹腔注射6-巯基嘌呤（27.5 mg/kg）。足月时，每 1 克饲料中添加 1,000 微克锌的母鼠，与饲喂较低水平锌的母鼠相比，药物引起的对生殖和胚胎发生的有害影响更少。对母体和胎儿组织的矿物质分析显示 6-巯基嘌呤对锌、铜、铁、钙和镁的代谢有显着影响。这项研究的结果表明，6-巯基嘌呤致畸可能部分归因于药物诱导的矿物质代谢变化。
The relationship between 6‐mercaptopurine‐induced alterations in mineral metabolism and the teratogenic effects of the drug were investigated. Pregnant Sprague‐Dawley rats were fed diets containing 4.5, 100, or 1,000 μg Zn per 1 g diet. On day 11 of gestation, dams were given intraperitoneal injections of 6‐mercaptopurine (27.5 mg/kg). At term, dams fed the 1,000‐μg Zn per 1 g diet showed fewer drug‐induced deleterious effects on reproduction and embryogenesis than did those fed lower levels of zinc. Mineral analysis of maternal and fetal tissues revealed pronounced effects of 6‐mercaptopurine on metabolism of zinc, copper, iron, calcium, and magnesium. The results of this study indicate that 6‐mercaptopurine teratogenesis may be due in part to drug‐induced changes in mineral metabolism.