Diverse roles of neurotensin agonists in the central nervous system.
Diverse roles of neurotensin agonists in the central nervous system.
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DOI：
10.3389/fendo.2013.00036
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发表时间：
2013
影响因子：
5.2
通讯作者：
Richelson E
中科院分区：
文献类型：
--
作者：
Boules M;Li Z;Smith K;Fredrickson P;Richelson E
神经降压素（NT）是一种存在于中枢神经系统（CNS）和胃肠道中的十三肽。NT在大脑中充当神经递质，在肠道中充当激素。此外，NT作为神经调节剂作用于几种神经递质系统，包括多巴胺能、血清素能、GABA能、多巴胺能和胆碱能系统。由于其与如此广泛的神经递质的关联，NT已经涉及几种CNS疾病的病理生理学，例如精神分裂症、药物滥用、帕金森病（PD）、疼痛、血压的中枢控制、进食障碍以及癌症和炎症。本文综述NT及其类似物在精神分裂症、内分泌功能、疼痛、精神兴奋剂滥用和PD中的作用。
Neurotensin (NT) is a tridecapeptide that is found in the central nervous system (CNS) and the gastrointestinal tract. NT behaves as a neurotransmitter in the brain and as a hormone in the gut. Additionally, NT acts as a neuromodulator to several neurotransmitter systems including dopaminergic, sertonergic, GABAergic, glutamatergic, and cholinergic systems. Due to its association with such a wide variety of neurotransmitters, NT has been implicated in the pathophysiology of several CNS disorders such as schizophrenia, drug abuse, Parkinson’s disease (PD), pain, central control of blood pressure, eating disorders, as well as, cancer and inflammation. The present review will focus on the role that NT and its analogs play in schizophrenia, endocrine function, pain, psychostimulant abuse, and PD.