Improved measurement of brain deformation during mild head acceleration using a novel tagged MRI sequence
Improved measurement of brain deformation during mild head acceleration using a novel tagged MRI sequence
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DOI：
10.1016/j.jbiomech.2014.09.010
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发表时间：
2014-11-07
影响因子：
2.4
通讯作者：
Pham, Dzung L.
中科院分区：
文献类型：
--
作者：
Knutsen, Andrew K.;Magrath, Elizabeth;Pham, Dzung L.
为了验证创伤性脑损伤的计算模型，并了解控制大脑机械反应的因素，需要在轻度加速过程中对人脑变形进行体内测量。标记磁共振成像是一种强大的、无创的跟踪组织运动的技术，已被用于量化活体人类受试者的大脑变形。然而，这些先前的研究需要从72到144个头部旋转来生成单个图像切片的变形数据，这阻碍了它用于研究单个受试者的整个大脑。本文介绍了一种新的方法，该方法显著降低了数据采集中的时间变异性，提高了位移估计的精度。在明胶幻影和三个人类受试者中优化采集参数，导致单个图像切片的旋转次数从72到144减少到少至8。在更少的重复中估计准确、分辨率高的位移和应变场的能力，将使在体内对整个人类大脑中由加速引起的变形进行全面研究成为可能。(C) 2014 Elsevier Ltd.版权所有。
In vivo measurements of human brain deformation during mild acceleration are needed to help validate computational models of traumatic brain injury and to understand the factors that govern the mechanical response of the brain. Tagged magnetic resonance imaging is a powerful, noninvasive technique to track tissue motion in vivo which has been used to quantify brain deformation in live human subjects. However, these prior studies required from 72 to 144 head rotations to generate deformation data for a single image slice, precluding its use to investigate the entire brain in a single subject. Here, a novel method is introduced that significantly reduces temporal variability in the acquisition and improves the accuracy of displacement estimates. Optimization of the acquisition parameters in a gelatin phantom and three human subjects leads to a reduction in the number of rotations from 72 to 144 to as few as 8 for a single image slice. The ability to estimate accurate, well-resolved, fields of displacement and strain in far fewer repetitions will enable comprehensive studies of acceleration-induced deformation throughout the human brain in vivo. (C) 2014 Elsevier Ltd. All rights reserved.