Neurotensin Receptor 1 Gene Polymorphisms Are Associated with Personality Traits in Healthy Chinese Individuals
Neurotensin Receptor 1 Gene Polymorphisms Are Associated with Personality Traits in Healthy Chinese Individuals
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神经降压素受体1基因多态性与健康中国人的人格特征相关
DOI：
10.1159/000356966
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发表时间：
2014-01-01
影响因子：
3.2
通讯作者：
Zhu, Gang
中科院分区：
文献类型：
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作者：
Ma, Hui;Huang, Yinglin;Zhu, Gang
目的：神经降压素受体1（NTR 1）是一种与神经降压素（NT）具有高亲和力的受体亚型。NT和NTR 1信号传导参与调节多巴胺系统。多巴胺系统的个体差异已被证明可以决定人格的某些方面，但迄今为止还没有研究调查NTR 1参与人格的生物决定。因此，我们在中国汉族人群中研究了这种联系。研究方法：我们对3种单核苷酸多态性（SNP）进行了基因分型。（rs6090453 C/G、rs6011914 C/G和rs 2427422 A/G）的基因多态性，收集了新奇寻求（NS）、伤害回避（HA）和奖赏依赖（RD）人格特质及其分量表的数据（采用三维人格问卷测量）。然后，我们研究了NTR 1基因多态性与每个人格特质之间的关联。结果如下：rs6090453 C/G基因型间HA 2、HA 3和RD 1评分差异有统计学意义rs6011914 C/G基因型之间HA 2和RD总分的差异（F分别为3.425、5.651、4.054，p分别为0.033、0.004、0.018 rs 2427422 A/G基因型之间的总RD（卡方2 = 7.301，p = 0.026）和RD 3（F = 4.119，p = 0.017）评分差异无统计学意义（分别为F = 4.080，3.712，p = 0.017，0.025）。rs6090453 C/G基因型之间的RD 1得分存在显著的男性特异性差异（F = 3.334，p = 0.037），总HA（F = 3.043，p = 0.049），HA2 rs6011914 C/G基因型和HA 2基因型之间的RD 3（F = 4.472，p = 0.012）和RD 3（卡方（2）= 6.997，p = 0.030）评分存在显著差异。rs 2427422 A/G基因型之间的总RD（卡方（2）= 7.032，p = 0.030）和RD 3（F = 4.563，p = 0.011）评分。我们还证明了rs6011914 C/G基因型之间的总RD评分的显著女性特异性差异（F = 3.677，p = 0.026）。3种SNPs基因型间NS总分及各因子分差异均无统计学意义（均p > 0.05）。结论：NTR 1基因的变异参与了HA和RD人格特质的生物学机制，但其影响受性别的影响。(C)2013 S. Karger AG，巴塞尔
Aims: Neurotensin receptor 1 (NTR1) is a neurotensin (NT) receptor subtype with a high affinity for NT. NT and NTR1 signaling are involved in modulating the dopamine system. Individual variations in the dopamine system have been demonstrated to determine certain dimensions of personality, but no studies have thus far investigated the involvement of the NTR1 in the biological determination of personality. We therefore examined this link in a Chinese Han population. Methods: We genotyped 3 single nucleotide polymorphisms (SNPs) (rs6090453C/G, rs6011914C/G, and rs2427422A/G) of the NTR1 gene and collected the data about the personality traits of novelty seeking (NS), harm avoidance (HA), and reward dependence (RD), as well as their subscales (measured by the Tridimensional Personality Questionnaire), in 575 healthy Chinese Han subjects. Then we examined the association between the 3 NTR1 gene polymorphisms and each personality trait. Results: There were significant differences in the HA2, HA3 and RD1 scores between rs6090453C/G genotypes (F = 3.425, 5.651, 4.054, p = 0.033, 0.004, 0.018, respectively), in the HA2 and total RD scores between rs6011914C/G genotypes (F = 4.080, 3.712, p = 0.017, 0.025, respectively), and in the total RD (chi(2) = 7.301, p = 0.026) and RD3 (F = 4.119, p = 0.017) scores between the rs2427422A/G genotypes. There were significant male-specific differences in the RD1 scores between the rs6090453C/G genotypes (F = 3.334, p = 0.037), in the total HA (F = 3.043, p = 0.049), HA2 (F = 4.472, p = 0.012) and RD3 (chi(2) = 6.997, p = 0.030) scores between the rs6011914C/G genotypes, and in the HA2 (F = 3.177, p = 0.043), total RD (chi(2) = 7.032, p = 0.030), and RD3 (F = 4.563, p = 0.011) scores between the rs2427422A/G genotypes. We also demonstrated a significant female-specific difference in the total RD scores between the rs6011914C/G genotypes (F = 3.677, p = 0.026). There was no significant difference in the total NS and subscale scores between the genotypes of all 3 SNPs (all p > 0.05). Conclusions: The variations in the NTR1 gene were involved in the biological mechanisms of HA and RD personality traits; however, the effect is influenced by gender. (C) 2013 S. Karger AG, Basel