Update on diagnosis and monitoring of cystic fibrosis-related diabetes mellitus (CFRD)
Update on diagnosis and monitoring of cystic fibrosis-related diabetes mellitus (CFRD)
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DOI：
10.1590/s0004-27302011000800016
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发表时间：
2011-11-01
期刊：
影响因子：
--
通讯作者：
Monte, Osmar
中科院分区：
文献类型：
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作者：
Noronha, Renata Maria de;Calliari, Luís Eduardo Procópio;Monte, Osmar
囊性纤维化（CF）是白种人中最常见的隐性常染色体疾病。患有囊性纤维化的儿童受益于医学和营养治疗的进步，这可以从这些患者生存率的改善中看出。生存率的提高带来了与 CF 相关的合并症的出现。如今，囊性纤维化相关糖尿病（CFRD）被认为是与 CF 相关的最常见并发症。它最早可以在婴儿期或青春期出现，在成年患者中患病率可高达 50%。由于其患病率高、早期发现困难以及所涉及的风险，近年来一些研究和共识集中在该疾病上，增加了有关 CFRD 的流行病学、病理生理学、预后和治疗的信息。本研究将介绍这些新概念的主要方面，以及当前对其诊断和随访的建议。 Arq Bras 内分泌代谢物。 2011;55(8):613-21
Cystic fibrosis (CF) is the most common recessive autosomal disease among Caucasian. Children with CF have benefitted from advances in medical and nutritional treatments, and this can be gleaned from the improvement in the survival of these patients. The increase in the survival rate brought with it the appearance of co-morbidities related to CF. Nowadays cystic fibrosis-related diabetes (CFRD) is considered the most common complication associated with CF. It can appear as early as infancy or adolescence, and its prevalence can be as high as 50% in adult patients. Because of its high prevalence, difficulties in early detection and the risks involved, in recent years several studies and consensuses have focused on this condition, adding information about the epidemiology, pathophysiology, prognosis and treatment of CFRD. The main aspects of these new concepts, as well as the current recommendations for its diagnosis and follow-up, will be presented in this study. Arq Bras Endocrinol Metab. 2011;55(8):613-21