Effect of fluid perfusion and cleansing on canine colonic motor activity.
Effect of fluid perfusion and cleansing on canine colonic motor activity.
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液体灌注和清洁对犬结肠运动活动的影响。
DOI：
10.1152/ajpgi.1992.262.1.g62
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Sarna,SK
中科院分区：
文献类型：
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作者：
Sarna,SK
我们研究了可吸收和不可吸收液体灌注和清洗对8只完整清醒犬结肠运动活动的影响。每只狗在结肠近端放置一根留置导管，在整个结肠上放置7个应变计传感器。禁食过夜后，对照记录3小时，灌注3小时，再作灌注后记录3小时。第二天，当结肠空时，进行3小时的记录。在对照组未清洁状态下，结肠表现出正常的迁移和非迁移运动复合物。可吸收电解质或不可吸收Colyte溶液的灌注立即破坏了迁移的运动复合物，取而代之的是在所有记录部位几乎连续但不规则的收缩。两种溶液均显著延长了近端、中端和远端结肠每小时收缩状态的平均和总持续时间。在开始灌注后大约40-80分钟，狗开始喷射出液体大便。这种类型的尿失禁与任何特定类型的运动活动无关。在灌注过程中，罕见地发生巨大的迁移性收缩，引起爆发性腹泻。在灌注后3小时内，迁移运动复合体仍处于中断状态。然而，第二天，空结肠表现出正常的迁移运动复合物。灌注时和空结肠内巨大迁移性收缩的频率明显高于未清洗的正常结肠。空结肠每小时结肠运动活动的总持续时间也大于正常未清洗结肠。我们得出结论，结肠中过多的液体会显著改变其运动模式。（摘要删节250字）
We investigated the effect of absorbable and nonabsorbable fluid perfusion and cleansing on colonic motor activity in eight intact conscious dogs. Each dog was instrumented with an indwelling catheter in the proximal colon and seven strain gauge transducers on the entire colon. After an overnight fast, a control recording was made for 3 h, followed by 3 h of perfusion and 3 additional h of postperfusion recording. Next day, a 3-h recording was made when the colon was empty. The colon exhibited normal migrating and nonmigrating motor complexes in the control uncleansed state. The perfusion of absorbable electrolyte or nonabsorbable Colyte solution immediately disrupted the migrating motor complexes and replaced them with almost continuous but irregular contractions at all recording sites. Both solutions significantly prolonged the mean and total duration per hour of contractile states in the proximal, middle, and distal colon. The dogs began to leak fluid stools in squirts approximately 40-80 min after the start of perfusion. This type of incontinence was not associated with any specific type of motor activity. Infrequently, giant migrating contractions occurred during perfusion and caused explosive diarrhea. The migrating motor complexes remained disrupted during the 3-h postperfusion period. However, on the next day, the empty colon exhibited normal migrating motor complexes. The frequency of giant migrating contractions during perfusion and in the empty colon was significantly greater than that in the normal uncleansed colon. The total duration per hour of colonic motor activity in the empty colon was also greater than that in the normal uncleansed colon. We conclude that excessive fluid in the colon significantly alters its motor pattern.(ABSTRACT TRUNCATED AT 250 WORDS)