HPA axis dysregulation following prenatal opiate exposure and postnatal withdrawal
HPA axis dysregulation following prenatal opiate exposure and postnatal withdrawal
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DOI：
10.1016/j.ntt.2004.09.004
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发表时间：
2005-01-01
影响因子：
2.9
通讯作者：
Schrott, LM
中科院分区：
文献类型：
--
作者：
Hamilton, KL;Harris, AC;Schrott, LM
我们研究了出生前暴露于长效阿片类药物/α-乙酰美沙酮（LAAM），出生后戒断对新生大鼠和成年大鼠下丘脑-垂体-肾上腺（HPA）轴反应性和成年大鼠焦虑样行为的影响。雌性大鼠在妊娠前28天经口灌胃给予LAAM（0、0.2或1.0 mg/kg/天），并在整个妊娠期间持续给药。幼鼠出生时被寄养在未经治疗的哺乳期的darris，并接受阿片类药物戒断。在出生后第18天（PND），产前阿片类药物暴露的雄性和雌性大鼠幼崽显示皮质酮反应降低2它的应用免疫应激和15分钟后的社会应激相比，对照组。相反，在成年期，产前阿片类药物治疗的大鼠表现出较高的皮质酮反应相比，产前水处理的控制在3它，但不是8它，免疫应激。与其他产前给药雄性组相比，产前接受1.0 mg/kg LAAM给药的雄性动物显示惊吓反应升高，但产前给药对雌性动物无影响。在旷场试验中，产前治疗对两种性别均无影响。这些结果表明，产前阿片类药物暴露，产后戒断失调的HPA轴反应的压力在新生儿和成人和差异影响成人焦虑样行为的男性和女性。(C)2004年爱思唯尔公司All rights reserved.
We examined the effects of prenatal exposure to the long acting opiate /-alpha-acetylmethadol (LAAM) followed by postnatal withdrawal on hypothalamic-pituitary-adrenal (HPA) axis reactivity in neonatal and adult rats and anxiety-like behavior in adult rats. Female rats were treated with LAAM (0, 0.2, or 1.0 mg/kg/day) via oral gavage for 28 days prior to and continuing throughout pregnancy. Pups were fostered at birth to nontreated, lactating darris and underwent opiate withdrawal. On postnatal day (PND) 18, prenatal opiate-exposed male and female rat pups displayed a decreased corticosterone response 2 It after the application of an immunological stressor and 15 min following a social stressor compared to controls. In contrast, in adulthood, prenatal opiate-treated rats showed a heightened corticosterone response compared to prenatal water-treated controls at 3 It, but not 8 It, following an immunological stressor. Males prenatally treated with 1.0 mg/kg LAAM displayed elevated startle responding compared to the other prenatally treated male groups, but there was no effect of prenatal treatment in females. There were no effects of prenatal treatment in the open field test in either sex. These results suggest that prenatal opiate exposure followed by postnatal withdrawal dysregulated the HPA axis response to stressors in the neonate and adult and differentially affected adult anxiety-like behavior in males and females.(C) 2004 Elsevier Inc. All rights reserved.