Patterns of macular ganglion cell abnormalities in various ocular conditions.
Patterns of macular ganglion cell abnormalities in various ocular conditions.
复制标题
各种眼部疾病中黄斑神经节细胞异常的模式。
DOI：
10.1167/iovs.14-14438
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发表时间：
2014
影响因子：
4.4
通讯作者：
Y. Hwang
中科院分区：
文献类型：
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作者：
Y. Hwang
我饶有兴趣地阅读了最近发表在《调查眼科与视觉科学》上的文章，内容涉及通过光学相干断层扫描 (OCT) 确定的黄斑神经节细胞内丛状层 (GCIPL) 厚度的青光眼诊断能力。 1-3 研究报告黄斑 GCIPL 厚度显示出良好的青光眼诊断能力。根据我的临床观察，GCIPL异常可见于多种眼部疾病，包括近视、黄斑变性、视网膜前膜（ERM）、垂体肿瘤引起的压迫性视神经病变以及青光眼。鉴于这些情况可能导致视野缺损，并且可能与青光眼同时出现，识别各种眼部疾病中黄斑 GCIPL 异常的不同模式可以通过使用 GCIPL 厚度测量来增强青光眼的诊断能力。在青光眼的早期阶段，黄斑 GCIPL 变薄主要位于水平中缝周围的颞下或颞上区域。 4 近视相关的GCIPL变薄主要位于下或上区域，表现为水平新月形异常区域。 4 值得注意的是，高度近视时，整个黄斑区域表现为异常 GCIPL 区域，难以判读。在早期黄斑变性的情况下，在中央凹周围观察到 GCIPL 变薄
I have read with great interest the recent articles regarding the glaucoma diagnostic ability of macular ganglion cell-inner plexiform layer (GCIPL) thickness as determined by optical coherence tomography (OCT) published in Investigative Ophthalmology & Visual Science. 1–3 The studies reported that the macular GCIPL thickness showed good glaucoma diagnostic ability. According to my clinical observations, GCIPL abnormality was found in various ocular conditions, including myopia, macular degeneration, epiretinal membrane (ERM), and compressive optic neuropathy due to pituitary gland tumor, as well as glaucoma. Given that these conditions can cause visual field defects, and can present simultaneously with glaucoma, identifying different patterns of macular GCIPL abnormalities in various ocular conditions may enhance glaucoma diagnostic ability by using GCIPL thickness measurement. In early stages of glaucoma, macular GCIPL thinning is predominantly located in the inferotemporal or superotemporal area around the horizontal raphe. 4 Thinning of GCIPL associated with myopia is mainly located in the inferior or superior area, and presents as a horizontal crescent-shaped abnormal area. 4 It should be noted that in very high myopia, the entire macular area appears as an abnormal GCIPL area, making it difficult to interpret. In conditions with early macular degeneration, GCIPL thinning is observed around the fovea