The integration of the corneal and limbal fibrils in the human eye
The integration of the corneal and limbal fibrils in the human eye
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DOI：
10.1016/s0006-3495(98)77695-7
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发表时间：
1998-11-01
影响因子：
3.4
通讯作者：
Meek, KM
中科院分区：
文献类型：
--
作者：
Newton, RH;Meek, KM
胶原纤维在人角膜和巩膜中的精确取向以及这两个区域在利姆布斯融合在一起的方法从未被确定，尽管这一信息很重要。从系统的力学考虑，组织中的原纤维取向有可能影响角膜的曲率，因此，通过推断，诸如涉及角膜的不正确曲率的散光的屈光问题可能与原纤维取向有关。高强度和小光束尺寸的同步辐射X射线源，使我们能够研究纤维的方向在死后的人角膜和巩膜。先前我们已经揭示了角膜中的两个优选取向方向（Meek，K. M.，T.布拉梅雷湾F.艾略特，T。Y. Gyi和C. J. Nave。1987. Curr. Eye Res.6：841-846）和利姆布斯中的角膜环（Newton，R. H、和K. M.温顺1998. Invest.眼用酚& Visual Sci. 39：1125-1134）。在这里，我们提出的结果，我们的调查这两个功能之间的关系。我们的测量结果表明，在两个首选方向取向的角膜纤维弯曲在利姆布斯周向运行。在这些结果的基础上，我们提出了一个模型，人类角膜和巩膜如何融合在一起。
The precise orientation of the collagen fibrils in human cornea and sclera and the method by which these two areas fuse together at the limbus have never been determined, despite the importance of this information. From a consideration of the mechanics of the system, fibril orientation in the tissue has the potential to affect the curvature of the cornea so, by inference, refractive problems such as astigmatism involving an incorrect curvature of the cornea may be related to fibril orientation. The high intensity and small beam size of a synchrotron x-ray source has enabled us to study fibril orientation in post-mortem human cornea and sclera. Previously we have revealed two preferred directions of orientation in the cornea (Meek, K. M., T. Blamires, G. F. Elliot, T. Y. Gyi, and C. J. Nave. 1987. Curr. Eye Res. 6:841-846) and a circumcorneal annulus in the limbus (Newton, R. H., and K. M. Meek. 1998. Invest. Ophthalmol. & Visual Sci. 39: 1125-1134). Here we present the results of our investigation into the relationship between these two features. Our measurements indicate that the corneal fibrils oriented in the two preferred directions bend at the limbus to run circumferentially. On the basis of these results we propose a model as to how the human cornea and sclera fuse together.