Asymmetric Bronsted Acid Catalyzed Synthesis of Triarylmethanes-Construction of Communesin and Spiroindoline Scaffolds
Asymmetric Bronsted Acid Catalyzed Synthesis of Triarylmethanes-Construction of Communesin and Spiroindoline Scaffolds
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DOI：
10.1002/anie.201505981
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发表时间：
2015-12-14
影响因子：
16.6
通讯作者：
Rueping, Magnus
中科院分区：
文献类型：
--
作者：
Liao, Hsuan-Hung;Chatupheeraphat, Adisak;Rueping, Magnus
偶氮-邻醌方法允许直接不对称合成具有四元立体中心的天然产物启发的吲哚支架。我们的方法可以在温和的反应条件下获得多种具有高对映选择性的communesin和螺络多林衍生物。可预测的替代模式被发现是我们区域分歧协议的关键。
Aza-ortho-quinone methides allow the straightforward asymmetric synthesis of natural-product-inspired indole scaffolds possessing a quaternary stereocenter. Our approach provides access to diverse communesin and spiroindoline derivatives with high enantioselectivity under mild reaction conditions. Predictable substitution patterns are found to be the key to our regiodivergent protocols.