Genomics and biology of Rudiviruses, a model for the study of virus-host interactions in Archaea.
Genomics and biology of Rudiviruses, a model for the study of virus-host interactions in Archaea.
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DOI：
10.1042/bst20120313
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发表时间：
2013-02-01
影响因子：
3.9
通讯作者：
Krupovic M
中科院分区：
文献类型：
--
作者：
Prangishvili D;Koonin EV;Krupovic M
微生物病毒，特别是感染泉古菌门的超嗜热古菌的病毒，构成了病毒圈中最不为人所知的部分之一。然而，由于最近几个小组的大量研究工作，古细菌病毒开始逐渐揭示它们的秘密。在本综述中，我们总结了目前的知识之一的新兴模式系统的研究crenarchaeal病毒，Rudiviridae。我们讨论了最近的进展，了解由rudivirus基因组编码的蛋白质的功能和结构，它们在病毒生命周期中的作用，并概述了该模型系统的进一步研究方向。此外，SIRV 2（冰岛硫化叶菌杆状病毒2）的基因组注释的修订。未来对古细菌病毒的研究，结合细菌和真核生物病毒的知识，应该会导致更好地了解病毒世界中病毒-宿主相互作用的多样性和进化。
Archaeal viruses, especially viruses that infect hyperthermophilic archaea of the phylum Crenarchaeota, constitute one of the least understood parts of the virosphere. However, owing to recent substantial research efforts by several groups, archaeal viruses are starting to gradually reveal their secrets. In the present review, we summarize the current knowledge on one of the emerging model systems for studies on crenarchaeal viruses, the Rudiviridae. We discuss the recent advances towards understanding the function and structure of the proteins encoded by the rudivirus genomes, their role in the virus life cycle, and outline the directions for further research on this model system. In addition, a revised genome annotation of SIRV2 (Sulfolobus islandicus rod-shaped virus 2) is presented. Future studies on archaeal viruses, combined with the knowledge on viruses of bacteria and eukaryotes, should lead to a better global understanding of the diversity and evolution of virus–host interactions in the viral world.