Olfactory dysfunction and COVID-19.
Olfactory dysfunction and COVID-19.
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DOI：
10.1016/j.otot.2022.04.010
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发表时间：
2022-06
期刊：
影响因子：
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通讯作者：
Goldstein, Bradley J
中科院分区：
文献类型：
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作者：
Choi, Rhea;Gupta, Rupali;Finlay, John B;Goldstein, Bradley J
在这里，我们提供了与COVID-19相关的嗅觉功能障碍的概述。我们提供了有关外周嗅觉系统的组织和功能的背景。本文对引起COVID-19的SARS-CoV-2感染引起的嗅觉缺失和嗅觉异常的相关文献进行了综述。特别注意的是集中在可能的机制，该病毒可能相互作用，并损害外周嗅觉系统的细胞群。从人类研究以及动物模型的证据被认为是。最后，我们讨论了当前对COVID后持续性嗅觉功能障碍患者的评估和管理建议，以及未来可能的研究方向。
Here, we provide an overview of olfactory dysfunction associated with COVID-19. We provide background regarding the organization and function of the peripheral olfactory system. A review of the relevant literature on anosmia and parosmia due to infection with SARS-CoV-2, the virus causing COVID-19, is provided. Specific attention is focused on possible mechanisms by which the virus may interact with and damage the cell populations of peripheral olfactory system. Evidence from human studies as well as animal models is considered. Finally, we discuss current recommendations for evaluation and management of patients with persistent post-COVID olfactory dysfunction, as well as possible future research directions.