An Ultra-Robust and Crystalline Redeemable Hydrogen-Bonded Organic Framework for Synergistic Chemo-Photodynamic Therapy
An Ultra-Robust and Crystalline Redeemable Hydrogen-Bonded Organic Framework for Synergistic Chemo-Photodynamic Therapy
复制标题
用于协同化学光动力疗法的超鲁棒且结晶可赎回的氢键有机框架
DOI：
10.1002/anie.201800354
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发表时间：
2018-06-25
影响因子：
16.6
通讯作者：
Cao, Rong
中科院分区：
文献类型：
--
作者：
Yin, Qi;Zhao, Peng;Cao, Rong
氢键有机骨架的低结构稳定性是阻碍其发展的一个棘手问题。现在提出了一种合理的设计方法来构建稳定的HOE。所得的霍夫（PFC-1）具有2122 m（2）g（-1）的高表面积和优异的化学稳定性（在浓盐酸中至少117天完好无损）。一种新的酸辅助结晶赎回方法被用来容易地治愈PFC-1的热损伤。PFC-1通过将光活性芘周期性地整合到坚固的框架中，可以有效地包封阿霉素（Doxo）用于协同化学-光动力学治疗，显示出与商业Doxo相当的治疗效果，但细胞毒性显著降低。这项工作表明，臭名昭著的稳定性问题的HOF可以通过合理的设计得到妥善解决，铺平了道路，开发强大的NOR和提供有前途的应用前景。
The low structural stability of hydrogen-bonded organic frameworks (HOFs) is a thorny issue retarding the development of HOFs. A rational design approach is now proposed for construction of a stable HOE The resultant HOF (PFC-1) exhibits high surface area of 2122 m(2) g(-1) and excellent chemical stability (intact in concentrated HCl for at least 117 days). A new method of acid-assisted crystalline redemption is used to readily cure the thermal damage to PFC-1. With periodic integration of photoactive pyrene in the robust framework, PFC-1 can efficiently encapsulate Doxorubicin (Doxo) for synergistic chemo-photodynamic therapy, showing comparable therapeutic efficacy with the commercial Doxo yet considerably lower cytotoxicily. This work demonstrates the notorious stability issue of HOFs can be properly addressed through rational design, paving a way to develop robust NOR and offering promising application perspectives.