Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies
Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies
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DOI：
10.1016/j.bbrc.2004.10.107
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发表时间：
2004-12-17
影响因子：
3.1
通讯作者：
Matsuoka, R
中科院分区：
文献类型：
--
作者：
Minamisawa, S;Oshikawa, J;Matsuoka, R
肌细胞膜和肌浆网之间的功能耦合是基于称为连接膜复合物（JMC）的不同结构。最近，junctophilins被发现是负责正常形成的JMC。在本研究中，我们发现，junctophilin 2型（JP-2），在心脏中的一个独特的异构体，被定位在小窝蛋白丰富的膜，JP-2的表达上调在正常发育和下调在肥大或扩张的心肌病小鼠模型。JP-2的表达水平可能与T-小管的发育和受损的Ca 2+诱导的Ca 2+释放有关。(C)2004年爱思唯尔公司All rights reserved.
Functional coupling between the sarcolemmal membrane and the sarcoplasmic reticulum is based on distinct structures called junctional membrane complexes (JMCs). Recently, junctophilins are found to be responsible for normal formation of JMCs. In the present study, we found that junctophilin type 2 (JP-2), a unique isoform in the heart, was localized in caveolin-rich membranes, and that the expression of JP-2 was up-regulated during normal development and down-regulated in a hypertrophic or a dilated cardiomyopathic mouse model. The expression levels of JP-2 may be associated with the development of T-tubules and impaired Ca2+-induced Ca2+ release in the heart. (C) 2004 Elsevier Inc. All rights reserved.