Structural analysis of the active site of porcine pancreatic elastase based on the X-ray crystal structures of complexes with trifluoroacetyl-dipeptide-anilide inhibitors.
Structural analysis of the active site of porcine pancreatic elastase based on the X-ray crystal structures of complexes with trifluoroacetyl-dipeptide-anilide inhibitors.
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基于三氟乙酰基-二肽-苯胺抑制剂复合物的X射线晶体结构对猪胰腺弹性蛋白酶活性位点的结构分析。
DOI：
10.1021/bi00010a008
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发表时间：
1995
期刊：
影响因子：
2.9
通讯作者：
Ringe,D
中科院分区：
文献类型：
--
作者：
Mattos,C;Giammona,DA;Petsko,GA;Ringe,D
1994年12月14日收到的修订版Mandarin pt ®摘要：介绍了与猪胰弹性蛋白酶复合的两种新的（三氟乙酰基）二肽p-（三氟甲基）苯胺（TFA-二肽-TFM）抑制剂的X射线晶体结构。TFA-瓦尔-Ala-TFM和TFA-Phe-Ala-TFM都与弹性蛋白酶结合，其中TFA基团在S1亚位点，瓦尔或Phe在S2亚位点，Ala在S3亚位点，TFM基团在S4亚位点。五种其他TFA-二肽-苯胺/弹性蛋白酶晶体结构是可用的（两种TFA-X-Ala-p-（三氟甲基）苯胺，X=
Revised Manuscript Received December 14, 1994® abstract: The X-ray crystal structures of two new (trifluoroacetyl) dipeptide p-(trifluoromethyl) anilide (TFA-dipeptide-TFM) inhibitors complexed to porcine pancreatic elastase are presented. TFA-Val-Ala-TFM and TFA-Phe-Ala-TFM both bind to elastase with the TFA group in the SI subsite, Val or Phe in the S2 subsite, Ala in the S3 subsite, and the TFM group in the S4 subsite. Five other TFA-dipeptide-anilide/elastase crystal structures are available (two TFA-X-Ala-p-(trifluoromethyl) anilide, X=