Immunity to asexual blood stages of Plasmodium:: Is resistance to acute malaria adaptive or innate
Immunity to asexual blood stages of Plasmodium:: Is resistance to acute malaria adaptive or innate
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DOI：
10.1016/s0169-4758(98)01298-8
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发表时间：
1998-09-01
期刊：
影响因子：
--
通讯作者：
Smith, NC
中科院分区：
文献类型：
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作者：
Fell, AH;Smith, NC
目前针对疟原虫血液阶段的免疫模型认为t细胞依赖过程起主要作用，最近的许多证据表明，th1型反应对控制急性疟疾至关重要。但这些数据经得起仔细推敲吗？在这里，Andy Fell和Nick Smith回顾了啮齿动物和人类研究的最新数据，并提出th1型反应可能对控制血液中的疟疾感染并不重要。
Current models of immunity to blood stages of Plasmodium invoke a primary role for T-cell dependent processes and much recent evidence implicates Th1-type responses as crucial to the control of acute malaria. But do these data stand up to close scrutiny? Here, Andy Fell and Nick Smith review recent data from rodent and human studies and suggest that Th1-type responses may not after all be important in controlling malaria infection in the blood.