Rapid fluorous Stille coupling reactions conducted under microwave irradiation
Rapid fluorous Stille coupling reactions conducted under microwave irradiation
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DOI：
10.1021/jo970362y
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发表时间：
1997-08-08
影响因子：
3.6
通讯作者：
Hallberg, A
中科院分区：
文献类型：
--
作者：
Larhed, M;Hoshino, M;Hallberg, A
在微波辐射下进行时，钯催化的氟代 Stille 与有机卤化物或三氟甲磺酸酯的交叉偶联反应仅需要 90-120 秒即可完成。类似的热反应大约需要1天。经过三相萃取（FC-84、二氯甲烷、水）和色谱法后，合成并分离出 14 种不同的偶联产物，收率良好。这些实施例扩展了含氟Stille偶联对于锡和卤化物/三氟甲磺酸盐组分的范围。建议在并行合成中应用。
Palladium-catalyzed fluorous Stille cross-coupling reactions with organic halides or triflates require only 90-120 s for completion when conducted under microwave irradiation. Comparable thermal reactions require about 1 day. Fourteen different coupling products were synthesized and isolated in good yields after three-phase extraction (FC-84, dichloromethane, water) and chromatography. The examples extend the scope of the fluorous Stille coupling with respect to both the tin and halide/triflate components. Applications in parallel synthesis are suggested.