Normative pediatric brain data for spatial normalization and segmentation differs from standard adult data
Normative pediatric brain data for spatial normalization and segmentation differs from standard adult data
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DOI：
10.1002/mrm.10606
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发表时间：
2003-10-01
影响因子：
3.3
通讯作者：
Holland, SK
中科院分区：
文献类型：
--
作者：
Wilke, M;Schmithorst, VJ;Holland, SK
由于两个人群之间的发育差异，基于成人参考数据的儿科脑成像数据的空间归一化和形态学研究可能不合适。在这项研究中，我们开始创建儿科模板和先验脑组织数据从一个大的集合正常，健康的儿童，比较它的标准成人数据中可用的广泛使用的成像软件解决方案（SPM 99，WDOCN，伦敦，英国）。采用四种不同的处理策略，我们发现我们的儿科数据和成人数据之间存在相当大的差异。我们的结论是，应谨慎使用成人先验信息分析小儿脑数据时。为了评估使用儿科先验大脑信息的效果，本研究中获得的数据可从我们的网站（www.irc.cchmc.org）提供给科学界。(C)2003 Wiley-Liss，Inc.
Spatial normalization and morphological studies of pediatric brain imaging data based on adult reference data may not be appropriate due to the developmental differences between the two populations. In this study, we set out to create pediatric templates and a priori brain tissue data from a large collection of normal, healthy children to compare it to standard adult data available within a widely used imaging software solution (SPM99, WDOCN, London, UK). Employing four different processing strategies, we found considerable differences between our pediatric data and the adult data. We conclude that caution should be used when analyzing pediatric brain data using adult a priori information. To assess the effects of using pediatric a priori brain information, the data obtained in this study is available to the scientific community from our website (www.irc.cchmc.org). (C) 2003 Wiley-Liss, Inc.