Adverse Metabolic Response to Regular Exercise: Is It a Rare or Common Occurrence?
Adverse Metabolic Response to Regular Exercise: Is It a Rare or Common Occurrence?
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DOI：
10.1371/journal.pone.0037887
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发表时间：
2012-05-30
期刊：
影响因子：
3.7
通讯作者：
Rankinen, Tuomo
中科院分区：
文献类型：
--
作者：
Bouchard, Claude;Blair, Steven N.;Rankinen, Tuomo
背景：不同的人对定期锻炼的反应不同。是否有人经历了心血管和糖尿病危险因素的不利变化从未得到解决。方法/主要发现：不良反应被定义为运动引起的变化，其恶化的危险因素超出了测量误差和预期的日常变化。60名受试者在三周的时间里测量了三次，并量化了静息收缩压(SBP)和空腹血浆高密度脂蛋白(HDLC)、甘油三酯(TG)和胰岛素(FI)的变化。计算技术误差(TE)，即由这些测量得出的受试者内标准偏差。对给定风险因素的不良反应被定义为距离无变化至少两个TE，但方向相反的变化。因此，如果SBP升高10 mm Hg或以上，TG升高0.42 mm o l/L或FI升高24pmoL/L或高密度脂蛋白胆固醇降低0.12 mm o l/L或以上，则出现不良反应。本分析使用了六项运动研究的完成者：来自传统型家庭研究的白人(N=473)和黑人(N=250)；来自德鲁(N=326)、IFAME(N=70)和STRRIDE(N=303)的白人和黑人；以及来自马里兰大学队列(N=160)和Jyveskyla大学研究(N=105)的白人，总共1,687名男性和女性。根据上述定义，126名受试者(8.4%)的FI发生了不利变化。不良反应发生率SBP为12.2%，TG为10.4%，HDL-C为13.3%。约7%的参与者在两个或两个以上的危险因素中经历了不良反应。结论/意义：心血管和糖尿病危险因素中经常锻炼会发生不良反应。识别这种无根据反应的预测因素以及如何预防它们将为个性化运动处方提供基础。
Background: Individuals differ in the response to regular exercise. Whether there are people who experience adverse changes in cardiovascular and diabetes risk factors has never been addressed.Methodology/Principal Findings: An adverse response is defined as an exercise-induced change that worsens a risk factor beyond measurement error and expected day-to-day variation. Sixty subjects were measured three times over a period of three weeks, and variation in resting systolic blood pressure (SBP) and in fasting plasma HDL-cholesterol (HDL-C), triglycerides (TG), and insulin (FI) was quantified. The technical error (TE) defined as the within-subject standard deviation derived from these measurements was computed. An adverse response for a given risk factor was defined as a change that was at least two TEs away from no change but in an adverse direction. Thus an adverse response was recorded if an increase reached 10 mm Hg or more for SBP, 0.42 mmol/L or more for TG, or 24 pmol/L or more for FI or if a decrease reached 0.12 mmol/L or more for HDL-C. Completers from six exercise studies were used in the present analysis: Whites (N = 473) and Blacks (N = 250) from the HERITAGE Family Study; Whites and Blacks from DREW (N = 326), from INFLAME (N = 70), and from STRRIDE (N = 303); and Whites from a University of Maryland cohort (N = 160) and from a University of Jyvaskyla study (N = 105), for a total of 1,687 men and women. Using the above definitions, 126 subjects (8.4%) had an adverse change in FI. Numbers of adverse responders reached 12.2% for SBP, 10.4% for TG, and 13.3% for HDL-C. About 7% of participants experienced adverse responses in two or more risk factors.Conclusions/Significance: Adverse responses to regular exercise in cardiovascular and diabetes risk factors occur. Identifying the predictors of such unwarranted responses and how to prevent them will provide the foundation for personalized exercise prescription.