The iron environment in heme and heme-antimalarial complexes of pharmacological interest
The iron environment in heme and heme-antimalarial complexes of pharmacological interest
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DOI：
10.1016/0162-0134(95)00212-x
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发表时间：
1996-07-01
影响因子：
3.9
通讯作者：
Silver, J
中科院分区：
文献类型：
--
作者：
Adams, PA;Berman, PAM;Silver, J
穆斯堡尔光谱已经被用来探测一些与疟疾相关的铁原卟啉IX配合物中的铁的电子环境。血红素与奎宁、氯喹和中草药抗疟青蒿琥酯的复合物的铁环境明显不同，这表明这些化合物的作用是保护血红素不聚合成不溶性血红素，并促进受保护的血红素运输到食物液泡膜，在那里它能够发挥其细胞毒性氧化还原催化活性。这里测定的纯化疟疾色素和合成-血红素的穆斯堡尔参数证实了这些物种的化学同一性。根据所提出的配合物结构，讨论了配合物的穆斯堡尔光谱。
Mossbauer spectroscopy has been utilized to probe the electronic environment of iron in a number of Ferriprotoporphyrin IX complexes of relevance to malaria. The markedly different iron environments found for the complexes of hemin with quinine, chloroquine, and the Chinese herbal antimalarial artesunate suggest that these compounds act by protecting the heme from polymerization to insoluble hemozoin, and by facilitating the transport of the protected heme to the food vacuole membrane where it is able to exercise its cytotoxic redox catalytic activity. Mossbauer parameters determined here for purified malaria pigment and synthetic beta-hematin confirm the chemical identical-ness of these species. The Mossbauer spectra of the complexes are discussed in light of the proposed structures of the complexes.