Distinct roles of visual, parietal, and frontal motor cortices in memory-guided sensorimotor decisions
Distinct roles of visual, parietal, and frontal motor cortices in memory-guided sensorimotor decisions
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DOI：
10.7554/elife.13764
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发表时间：
2016-08-04
期刊：
影响因子：
7.7
通讯作者：
Sur, Mriganka
中科院分区：
文献类型：
--
作者：
Goard, Michael J.;Pho, Gerald N.;Sur, Mriganka
将特定的感觉特征映射到未来的运动动作是哺乳动物神经系统的关键能力。我们研究了视觉（V1），后顶叶（PPC）和额叶运动（fMC）皮层的感觉运动映射在小鼠在记忆引导的视觉辨别任务的性能的作用。大规模的钙成像显示，V1，PPC和fMC神经元表现出异质性的反应，跨越所有的任务时期（刺激，延迟，反应）。人群分析表明，独特的编码的刺激身份和行为选择信息的区域，与V1编码刺激，fMC编码选择，甚至在试验的早期，和PPC复用的两个变量。行为过程中的光遗传抑制表明，所有的区域都是必要的刺激时期，但只有fMC需要在延迟和响应时期。因此，刺激身份可以快速转换为行为选择，在转换期间需要V1，PPC和fMC，但只有fMC用于在执行之前在内存中维护选择。
Mapping specific sensory features to future motor actions is a crucial capability of mammalian nervous systems. We investigated the role of visual (V1), posterior parietal (PPC), and frontal motor (fMC) cortices for sensorimotor mapping in mice during performance of a memory-guided visual discrimination task. Large-scale calcium imaging revealed that V1, PPC, and fMC neurons exhibited heterogeneous responses spanning all task epochs (stimulus, delay, response). Population analyses demonstrated unique encoding of stimulus identity and behavioral choice information across regions, with V1 encoding stimulus, fMC encoding choice even early in the trial, and PPC multiplexing the two variables. Optogenetic inhibition during behavior revealed that all regions were necessary during the stimulus epoch, but only fMC was required during the delay and response epochs. Stimulus identity can thus be rapidly transformed into behavioral choice, requiring V1, PPC, and fMC during the transformation period, but only fMC for maintaining the choice in memory prior to execution.