Augmentation of sensitivity to urinary pheromone and excreting of urinary pheromone by sexual experiences
Augmentation of sensitivity to urinary pheromone and excreting of urinary pheromone by sexual experiences
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DOI：
10.1093/chemse/bjh152
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发表时间：
2005-01-01
期刊：
影响因子：
3.5
通讯作者：
Kashiwayanagi, M
中科院分区：
文献类型：
--
作者：
Kashiwayanagi, M
信息素信号提供了关于各种哺乳动物种群中不同成员的身份、性别、内分泌和社会地位的特定信息（Halpern，1987; Wysocki和Meredith，1987）。从雄性和雌性大鼠排泄的尿中的信息素诱导性腺功能的各种变化，例如在没有性交和交配的情况下的反射排卵（Johns等人，1978），雌性大鼠的发情周期从5天减少到4天（Chateau等人，1976）和共同生活的雌性大鼠的发情同步性（McClintock，1978）。犁鼻器是犁鼻系统的外周化学感受器。在啮齿动物犁鼻器中，尿信息素对性腺功能的调节作用已被证实。犁鼻感觉神经元将信息投射到位于主嗅球背尾侧的副嗅球。Fos的诱导已被广泛用作研究脑的许多不同区域内的神经元群体的兴奋性的测定。免疫组织学方法已被用于可视化Fos作为识别被刺激激活的神经元的手段。通过去除大鼠AOB中的犁鼻器消除了尿信息素诱导的Fos免疫反应性的增加，这表明信息素信息被传递到AOB处的神经元（Inamura等人，1999年a）。
Pheromonal signals provide specific information concerning the identity, gender, endocrine, and social status of different members of the population in a variety of mammals (Halpern, 1987; Wysocki and Meredith, 1987). Pheromones in urine excreted from male and female rats induce various changes in gonadal functions such as reflex ovulation in the absence of coitus and mounting (Johns et al., 1978), a reduction in the oestrous cycle of female rats from 5 to 4 days (Chateau et al., 1976) and oestrous synchrony among female rats living together (McClintock, 1978). The vomeronasal organ is the peripheral chemoreceptor organ of the vomeronasal system. Regulation of gonadal functions by urinary pheromones has been well established in the rodent vomeronasal organ. Vomeronasal sensory neurons project information to the accessory olfactory bulb (AOB) located on the dorso-caudal surface of the main olfactory bulb. The induction of Fos has been widely used as an assay for studying the excitability of populations of neurons within many different regions of the brain. Immunohistological methods have been used to visualize Fos as a means of identifying neurons that are activated by stimulation. The urinary pheromone-induced increases in Fos-immunoreactivities were eliminated by the removal of the vomeronasal organ in the AOB of rats, indicating that pheromonal information is transmitted to neurons at the AOB (Inamura et al., 1999a).